Detailed information of TA system TA147688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1939190..1939497
• Replicon: chromosome
• Accession: NZ_CP047787
• Organism: Staphylococcus aureus strain UP_1108

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3S97_RS09420
• Protein ID: WP_011447039.1
• Coordinates: 1939321..1939497 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1939190..1939329 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S97_RS09380	1934529..1934789	+	261	WP_001791826.1	hypothetical protein	-
E3S97_RS09385	1934842..1935192	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3S97_RS09390	1935877..1936326	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3S97_RS09395	1936421..1936756	-	336	Protein_1802	SH3 domain-containing protein	-
E3S97_RS09400	1937406..1937897	-	492	WP_000919350.1	staphylokinase	-
E3S97_RS09405	1938088..1938843	-	756	WP_064131634.1	CHAP domain-containing protein	-
E3S97_RS09410	1938855..1939109	-	255	WP_000611512.1	phage holin	-
E3S97_RS09415	1939161..1939268	+	108	WP_001791821.1	hypothetical protein	-
-	1939190..1939329	+	140	NuclAT_0	-	Antitoxin
-	1939190..1939329	+	140	NuclAT_0	-	Antitoxin
-	1939190..1939329	+	140	NuclAT_0	-	Antitoxin
-	1939190..1939329	+	140	NuclAT_0	-	Antitoxin
E3S97_RS09420	1939321..1939497	-	177	WP_011447039.1	putative holin-like toxin	Toxin
E3S97_RS09425	1939647..1939943	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
E3S97_RS09430	1940001..1940288	-	288	WP_001040261.1	hypothetical protein	-
E3S97_RS09435	1940335..1940487	-	153	WP_001153681.1	hypothetical protein	-
E3S97_RS09440	1940477..1944262	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1934842..1958257	23415

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147688 WP_011447039.1 NZ_CP047787:c1939497-1939321 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147688 NZ_CP063214:c3700348-3699974 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCTGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
ACGGTTGCTGGACCAGCATTACGGCCTTACGCTGGATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCGGGTATTTCACTGTGCGATGCAGTGAACTTTCTCGTTGAAAAATACACACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGAGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT147688 NZ_CP047787:1939190-1939329 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin