Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2302998..2303521 Replicon chromosome
Accession NZ_CP047786
Organism Staphylococcus aureus strain UP_1150

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag E3S98_RS11180 Protein ID WP_000074043.1
Coordinates 2303255..2303521 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag E3S98_RS11175 Protein ID WP_000587618.1
Coordinates 2302998..2303255 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S98_RS11155 2298078..2299271 + 1194 WP_000675406.1 MFS transporter -
E3S98_RS11160 2299495..2300244 - 750 WP_000072463.1 hypothetical protein -
E3S98_RS11165 2300439..2302016 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
E3S98_RS11170 2302184..2302639 - 456 WP_000732091.1 DUF1307 domain-containing protein -
E3S98_RS11175 2302998..2303255 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3S98_RS11180 2303255..2303521 + 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
E3S98_RS11185 2303878..2304954 + 1077 WP_045172647.1 M42 family metallopeptidase -
E3S98_RS11190 2305202..2305864 + 663 WP_006191024.1 ATP-binding cassette domain-containing protein -
E3S98_RS11195 2305857..2306633 + 777 WP_006191020.1 iron export ABC transporter permease subunit FetB -
E3S98_RS11200 2307027..2308214 + 1188 WP_000026187.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T147675 WP_000074043.1 NZ_CP047786:2303255-2303521 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T147675 NZ_CP063214:c382127-382020 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT147675 WP_000587618.1 NZ_CP047786:2302998-2303255 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT147675 NZ_CP063214:382180-382241 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References