Detailed information of TA system TA147666

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2338063..2338247
• Replicon: chromosome
• Accession: NZ_CP047785
• Organism: Staphylococcus aureus strain UP_1186

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3S99_RS11520
• Protein ID: WP_000482647.1
• Coordinates: 2338063..2338170 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2338187..2338247 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3S99_RS11495	2333427..2333900	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
E3S99_RS11500	2334023..2335234	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
E3S99_RS11505	2335414..2336073	-	660	WP_000831298.1	membrane protein	-
E3S99_RS11510	2336133..2337275	-	1143	WP_001176860.1	glycerate kinase	-
E3S99_RS11515	2337543..2337929	+	387	WP_000779354.1	flippase GtxA	-
E3S99_RS11520	2338063..2338170	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2338187..2338247	-	61	-	-	Antitoxin
E3S99_RS11525	2338197..2338364	+	168	WP_000301894.1	hypothetical protein	-
E3S99_RS11530	2338742..2340481	+	1740	WP_001064831.1	ABC transporter ATP-binding protein/permease	-
E3S99_RS11535	2340530..2342263	+	1734	WP_000488492.1	ABC transporter ATP-binding protein/permease	-
E3S99_RS11540	2342494..2342661	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147666 WP_000482647.1 NZ_CP047785:2338063-2338170 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147666 NZ_CP063200:1161253-1162206 [Vibrio sp. SCSIO 43132]
ATGGAAAAACTAAAACAACAATTCCTTGAGGTTTCCGATGCGCTTGAGCTCGGAAACCCAGCCATCATTGAAAAAGATTA
TTGGGTTGTTGCGCTATTGTCTGAGCTAGCTAAAGTGAAGGCAGACTCTCATCAAATGGTCTTTTCTGGCGGTACAGCCC
TTGCAAAATCAAACGTTAAAATTCTTAGAATGTCTGAAGATGTAGACATTAAATTAATCCCCAAACCAGCGTTTAATGAG
CTAAGCCGCGCTAAAAAGAAAGCGGCTCGTAAAATATGCATTAACGAGATCGAACAGATCATCACTCAATCAAAGCTATT
TACGATTGAAGAGCGTACTGTAAATGATGAATTTCGTTATGTTGAATTCGAATTCAGATACCCACAGCAATTTAGCCAGT
CACCATGCCTTCGTCCCATCATTAAACTGGAGTTGATGGAAACAATCCCGTTACTCGATGTAGAACCCCGCAACATTCAA
TCACTGGTTGCAGAGCTGTATAAACAACCACAAGAAGTGAGCGCTTTCGATTGCATTTCTATCCACGCTACTTTAGTTGA
AAAAGTGATTTCAATGTTACGCCGTACCATGTCGGTGAAGCGCGATGCACAGCGTAAGGATGATGCCACACTAGTACGCC
ATATCTATGATGTTTACTGCATTTTAAAGACAGAAGAGCAGACAGAAAGCCTAGACCTTGAGGCGCTAACACCGTTATTT
AAAACAGTGTTAGAAGAGGATATTGAGCGTTTTGGCAGTCAACATGCAGAGTTTGTTGCCAACCCAAAACAAGAGCTACA
ACTCGGATTGCAAGAAATTGAAGAAAACCCAGCCTTCCACCAACGCTTCCAAGACTTTGTTACGCCAATGGTGTTTAGCG
CCGAGCCTCATGATTTTGATACCTGTTTTGCGTCTTTTAAGCGCATTGCAGAGTCGTTAATTGAAGCAATTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147666 NZ_CP047785:c2338247-2338187 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin