Detailed information of TA system TA147656

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2378523..2378707
• Replicon: chromosome
• Accession: NZ_CP047784
• Organism: Staphylococcus aureus strain UP_1209

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T00_RS11710
• Protein ID: WP_000482647.1
• Coordinates: 2378600..2378707 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2378523..2378583 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T00_RS11695	2374033..2374200	-	168	WP_001789205.1	hypothetical protein	-
E3T00_RS11700	2374431..2376164	-	1734	WP_070005454.1	ABC transporter ATP-binding protein/permease	-
E3T00_RS11705	2376189..2377952	-	1764	WP_043044953.1	ABC transporter ATP-binding protein/permease	-
-	2378523..2378583	+	61	-	-	Antitoxin
E3T00_RS11710	2378600..2378707	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3T00_RS11715	2378841..2379227	-	387	WP_000779357.1	flippase GtxA	-
E3T00_RS11720	2379495..2380637	+	1143	WP_001176863.1	glycerate kinase	-
E3T00_RS11725	2380697..2381356	+	660	WP_043044952.1	membrane protein	-
E3T00_RS11730	2381538..2382749	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3T00_RS11735	2382872..2383345	-	474	WP_043044951.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147656 WP_000482647.1 NZ_CP047784:c2378707-2378600 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147656 NZ_CP063169:c1086947-1086624 [Haloactinobacterium sp. RN3S43]
GTGAACCGCGGCGAGATCTGGACCGTGGCGGGCGGCGTGTATGCGAGCAAGCCGAGGCCGGCCCTCATTGTTCAGGACGA
CGCGTTCGCCCAGACCGGCTCGGTGACGGTGTTGCCATTAACGACGTCCCTGACCGATGCACCATTGCTGCGGCTCCGGT
TGCGATCCGGCGAGGCGGGCCTCACCCGGCACAGCGACATCATGATCGACAAACTCACCACGGTGCGGCGATCCAGCGTC
GGCACACGCGTGGGCCGCGTGAGCACCGAGCGCCTGGTCGAGATCGAACGAGCGCTGATGGCGTTCCTCGGGATGGCTCG
CTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147656 NZ_CP047784:2378523-2378583 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin