Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2353220..2353737 | Replicon | chromosome |
| Accession | NZ_CP047784 | ||
| Organism | Staphylococcus aureus strain UP_1209 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | E3T00_RS11575 | Protein ID | WP_000113262.1 |
| Coordinates | 2353220..2353486 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | E3T00_RS11580 | Protein ID | WP_000584499.1 |
| Coordinates | 2353486..2353737 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3T00_RS11545 | 2348646..2349182 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| E3T00_RS11550 | 2349416..2350240 | - | 825 | WP_000594630.1 | formate/nitrite transporter family protein | - |
| E3T00_RS11555 | 2350456..2350641 | - | 186 | WP_000230293.1 | hypothetical protein | - |
| E3T00_RS11560 | 2350725..2351192 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| E3T00_RS11565 | 2351378..2352925 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| E3T00_RS11570 | 2353114..2353185 | - | 72 | Protein_2221 | hypothetical protein | - |
| E3T00_RS11575 | 2353220..2353486 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| E3T00_RS11580 | 2353486..2353737 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| E3T00_RS11585 | 2353902..2354003 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| E3T00_RS11590 | 2354010..2354609 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| E3T00_RS11595 | 2354628..2354990 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| E3T00_RS11600 | 2355245..2356495 | + | 1251 | WP_043044961.1 | FemA/FemB family glycyltransferase FmhA | - |
| E3T00_RS11605 | 2356592..2357323 | - | 732 | WP_043044960.1 | amino acid ABC transporter ATP-binding protein | - |
| E3T00_RS11610 | 2357320..2358039 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T147655 WP_000113262.1 NZ_CP047784:c2353486-2353220 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T147655 NZ_CP063167:1888530-1888949 [Variovorax paradoxus]
ATGATCGTCCTCGACACCAACGTCGTCTCCGAGGCGATGAAACCGGAGCCGGATGCGGCCGTAAGGGCGTGGTTGAACGA
CCAGGCGGCAGAGAGTCTTTACCTGTCCAGCGTCACGCTGGCCGAGTTGCTGTTCGGGATCCGGGCGTTGCCCGCGGGCA
AGCGCAAGAATCTGCTCGACCGAGCCCTGCGTGAGTTGCTGGAGCTGTTCAAGGATCGTGTTCTTCCGTTCGACACGGAT
GCAGCGCGCCACTATGCAGACCTGGCCGTAACCGCCAGGAGCGGCGGTCGCGGCTTCCCGACGCCGGATGGCTATATCGC
GGCCATTGCGGCATCGCGTGGCTTCATCGTGGCATCGCGCGACACGTCGCCCTATGAAGCGGCGGGCCTGACGGTCATCA
ACCCCTGGACAGAGGCGTAG
ATGATCGTCCTCGACACCAACGTCGTCTCCGAGGCGATGAAACCGGAGCCGGATGCGGCCGTAAGGGCGTGGTTGAACGA
CCAGGCGGCAGAGAGTCTTTACCTGTCCAGCGTCACGCTGGCCGAGTTGCTGTTCGGGATCCGGGCGTTGCCCGCGGGCA
AGCGCAAGAATCTGCTCGACCGAGCCCTGCGTGAGTTGCTGGAGCTGTTCAAGGATCGTGTTCTTCCGTTCGACACGGAT
GCAGCGCGCCACTATGCAGACCTGGCCGTAACCGCCAGGAGCGGCGGTCGCGGCTTCCCGACGCCGGATGGCTATATCGC
GGCCATTGCGGCATCGCGTGGCTTCATCGTGGCATCGCGCGACACGTCGCCCTATGAAGCGGCGGGCCTGACGGTCATCA
ACCCCTGGACAGAGGCGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT147655 WP_000584499.1 NZ_CP047784:c2353737-2353486 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT147655 NZ_CP063167:1888275-1888529 [Variovorax paradoxus]
ATGGCAATCCTGACGGTAAGAAATGTGCCCGACGACGTGCACCGCGCCTTGCGCGTGCGGGCTGCCCAGCATGGCCGCAG
TACGGAAGCGGAGGTGCGCGAGATTCTGGCGTCCGTGGTCAAGCCGGAGAAGCGCGTGCTCGTGGGAGACGCCTTGGCTG
CCATCGGTCGCAAGATCGGCCTGACCAATGAGGATTTCGCGGTCTTCGAGAATGTGCGCGACAAGACGCCGGCCAAACCG
CTGAGCTTCGACTGA
ATGGCAATCCTGACGGTAAGAAATGTGCCCGACGACGTGCACCGCGCCTTGCGCGTGCGGGCTGCCCAGCATGGCCGCAG
TACGGAAGCGGAGGTGCGCGAGATTCTGGCGTCCGTGGTCAAGCCGGAGAAGCGCGTGCTCGTGGGAGACGCCTTGGCTG
CCATCGGTCGCAAGATCGGCCTGACCAATGAGGATTTCGCGGTCTTCGAGAATGTGCGCGACAAGACGCCGGCCAAACCG
CTGAGCTTCGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|