Detailed information of TA system TA147653

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2093006..2093268
• Replicon: chromosome
• Accession: NZ_CP047784
• Organism: Staphylococcus aureus strain UP_1209

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T00_RS10225
• Protein ID: WP_001802298.1
• Coordinates: 2093164..2093268 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2093006..2093169 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T00_RS10205	2089189..2089854	-	666	WP_001024095.1	SDR family oxidoreductase	-
E3T00_RS10210	2090006..2090326	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T00_RS10215	2090328..2091308	+	981	WP_043044038.1	CDF family zinc efflux transporter CzrB	-
E3T00_RS10220	2091574..2092665	+	1092	WP_000495682.1	hypothetical protein	-
-	2093006..2093169	+	164	-	-	Antitoxin
E3T00_RS10225	2093164..2093268	-	105	WP_001802298.1	hypothetical protein	Toxin
E3T00_RS10230	2093948..2094106	+	159	WP_001792784.1	hypothetical protein	-
E3T00_RS10235	2094764..2095621	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
E3T00_RS10240	2095689..2096471	-	783	WP_043044040.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147653 WP_001802298.1 NZ_CP047784:c2093268-2093164 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147653 NZ_CP063167:1145562-1145942 [Variovorax paradoxus]
ATGACGCTGGTGTTGGTTGATACCTCGGTTTGGGTTGATCATTTTCGCGCGCGGAACTCCACCTTGGAGCAGCTGCTCGG
GCTTGACCAAGTATTGATTCATCCGATGGTGATAGGGGAGCTTGCATGCGGTACACCGCCAGCGCGTACCCAGACGCTCG
GATATCTGCATCACCTGCAACATGTGCAGCAAGCCAGCCTGCGCGAAGTGCTCCTCTTCATCGAAAAAGAGCGTCTCTTT
GGATTGGGGTGTGGCCTCGTGGACCTGACCCTTGTGGCATCGACGCTGATGACGCCTGGCGCCGAACTGTGGTCTCTAGA
CAAGCGCCTGAACGATATGACGCAAAGGTTTGCGGTCGGGTACCGACCCGCTGTCCATTGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT147653 NZ_CP047784:2093006-2093169 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin