Detailed information of TA system TA147645

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2402256..2402440
• Replicon: chromosome
• Accession: NZ_CP047783
• Organism: Staphylococcus aureus strain UP_1313

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T03_RS11750
• Protein ID: WP_000482647.1
• Coordinates: 2402333..2402440 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2402256..2402316 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T03_RS11730	2397766..2397933	-	168	WP_031845053.1	hypothetical protein	-
E3T03_RS11735	2398164..2399897	-	1734	WP_000488493.1	ABC transporter ATP-binding protein/permease	-
E3T03_RS11740	2399922..2401685	-	1764	WP_001064822.1	ABC transporter ATP-binding protein/permease	-
E3T03_RS11745	2402139..2402306	-	168	WP_000301893.1	hypothetical protein	-
-	2402256..2402316	+	61	-	-	Antitoxin
E3T03_RS11750	2402333..2402440	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3T03_RS11755	2402573..2402959	-	387	WP_000779353.1	flippase GtxA	-
E3T03_RS11760	2403227..2404369	+	1143	WP_001176863.1	glycerate kinase	-
E3T03_RS11765	2404429..2405088	+	660	WP_000831298.1	membrane protein	-
E3T03_RS11770	2405271..2406482	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
E3T03_RS11775	2406605..2407078	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147645 WP_000482647.1 NZ_CP047783:c2402440-2402333 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147645 NZ_CP063162:c987820-987401 [Geobacillus stearothermophilus]
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAGGCATGCATCGATT
TGGCCATGCATATTGTGGCCGAGCAGAAATTCGGATTGCCGCAGCATAGCCGCGATGCATTCGCTCTCCTCGAAGAACAT
GGGGTCATCTCCCCTTCCATAAGCAAAAAGATGAAGGCGATGGTCGGATTCCGCAACATCGCCGTTCACGACTATCAACA
ACTGAACCTTGGCATCTTGCAAGCCATCGTCGAACACCATCTTGATGATTTCAAACAATTTACGAAAGCCATCCTCGATT
ATGCTAAGAAAAACAGCTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT147645 NZ_CP047783:2402256-2402316 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin