Detailed information of TA system TA147644

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2116469..2116732
• Replicon: chromosome
• Accession: NZ_CP047783
• Organism: Staphylococcus aureus strain UP_1313

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T03_RS10290
• Protein ID: WP_001802298.1
• Coordinates: 2116628..2116732 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2116469..2116633 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T03_RS10270	2112706..2113371	-	666	WP_001024088.1	SDR family oxidoreductase	-
E3T03_RS10275	2113523..2113843	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
E3T03_RS10280	2113845..2114822	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
E3T03_RS10285	2115088..2116179	+	1092	WP_000495695.1	hypothetical protein	-
-	2116469..2116633	+	165	-	-	Antitoxin
E3T03_RS10290	2116628..2116732	-	105	WP_001802298.1	hypothetical protein	Toxin
E3T03_RS10295	2116893..2117376	-	484	Protein_1980	recombinase family protein	-
E3T03_RS10300	2117419..2118555	-	1137	Protein_1981	SAP domain-containing protein	-
E3T03_RS10305	2118844..2118936	+	93	WP_031844941.1	hypothetical protein	-
E3T03_RS10310	2119631..2120488	-	858	WP_031844942.1	Cof-type HAD-IIB family hydrolase	-
E3T03_RS10315	2120556..2121338	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147644 WP_001802298.1 NZ_CP047783:c2116732-2116628 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147644 NZ_CP063162:223503-223853 [Geobacillus stearothermophilus]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGATCTTTCCCCGGTTGTTGGCTCAGAGCAGGGCGGCGTCCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGCTTCAGTCCAACGGTTATTGTAGCGGCGATCACGGCGCAAATCCAAAAGG
CAAAGCTGCCGACGCATGTCGAGATCGATGCGAAGCGCTACGGGTTTGAGCGGGACTCGGTCATTTTGCTTGAACAAATC
CGTACGATTGATAAGCAGCGGCTGACTGACAAAATCACCCATCTGGATGATGAGATGATGGACAAAGTCGATGAAGCGCT
GCAAATCAGCTTAGGGCTGATCGACTTTTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT147644 NZ_CP047783:2116469-2116633 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin