Detailed information of TA system TA147636

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2271501..2271685
• Replicon: chromosome
• Accession: NZ_CP047782
• Organism: Staphylococcus aureus strain UP_1352

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T04_RS11605
• Protein ID: WP_000482647.1
• Coordinates: 2271578..2271685 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2271501..2271561 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T04_RS11595	2267409..2269142	-	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
E3T04_RS11600	2269167..2270930	-	1764	WP_001064829.1	ABC transporter ATP-binding protein/permease	-
-	2271501..2271561	+	61	-	-	Antitoxin
E3T04_RS11605	2271578..2271685	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3T04_RS11610	2271819..2272205	-	387	WP_000779351.1	flippase GtxA	-
E3T04_RS11615	2272473..2273615	+	1143	WP_001176855.1	glycerate kinase	-
E3T04_RS11620	2273675..2274334	+	660	WP_000831298.1	membrane protein	-
E3T04_RS11625	2274516..2275727	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3T04_RS11630	2275850..2276323	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2266124..2267071	947

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147636 WP_000482647.1 NZ_CP047782:c2271685-2271578 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147636 NZ_CP063154:c72571-72173 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGCACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147636 NZ_CP047782:2271501-2271561 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin