Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2245124..2245641 Replicon chromosome
Accession NZ_CP047782
Organism Staphylococcus aureus strain UP_1352

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3T04_RS11465 Protein ID WP_000251928.1
Coordinates 2245124..2245390 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3T04_RS11470 Protein ID WP_000584497.1
Coordinates 2245390..2245641 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T04_RS11440 2240332..2240868 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
E3T04_RS11445 2241336..2242160 - 825 WP_000594640.1 formate/nitrite transporter family protein -
E3T04_RS11450 2242363..2242545 - 183 WP_000079140.1 hypothetical protein -
E3T04_RS11455 2242631..2243098 - 468 WP_000153340.1 SRPBCC domain-containing protein -
E3T04_RS11460 2243284..2244831 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T04_RS11465 2245124..2245390 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3T04_RS11470 2245390..2245641 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T04_RS11475 2245805..2245905 - 101 Protein_2215 hypothetical protein -
E3T04_RS11480 2245912..2246511 - 600 WP_000162804.1 DsbA family protein -
E3T04_RS11485 2246530..2246892 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E3T04_RS11490 2247147..2248397 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3T04_RS11495 2248494..2249225 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3T04_RS11500 2249222..2249941 - 720 WP_000479574.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T147635 WP_000251928.1 NZ_CP047782:c2245390-2245124 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147635 NZ_CP063154:42046-42204 [Escherichia coli]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT147635 WP_000584497.1 NZ_CP047782:c2245641-2245390 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT147635 NZ_CP063154:41783-41981 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGATTATTTTCAGGAAGAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References