Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1747564..1747978 | Replicon | chromosome |
| Accession | NZ_CP047782 | ||
| Organism | Staphylococcus aureus strain UP_1352 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A6B5KJM6 |
| Locus tag | E3T04_RS08830 | Protein ID | WP_001065110.1 |
| Coordinates | 1747727..1747978 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | E3T04_RS14850 | Protein ID | WP_000028424.1 |
| Coordinates | 1747564..1747737 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E3T04_RS08775 | 1743003..1744280 | - | 1278 | WP_160200007.1 | PBSX family phage terminase large subunit | - |
| E3T04_RS08780 | 1744267..1744707 | - | 441 | WP_001003272.1 | terminase small subunit | - |
| E3T04_RS08785 | 1744894..1745316 | - | 423 | WP_000162696.1 | RinA family phage transcriptional activator | - |
| E3T04_RS08790 | 1745340..1745486 | - | 147 | WP_000990005.1 | hypothetical protein | - |
| E3T04_RS08795 | 1745487..1745660 | - | 174 | WP_000595244.1 | transcriptional activator RinB | - |
| E3T04_RS08800 | 1745660..1746046 | - | 387 | WP_201750721.1 | hypothetical protein | - |
| E3T04_RS08805 | 1746036..1746272 | - | 237 | WP_000483477.1 | hypothetical protein | - |
| E3T04_RS08810 | 1746297..1746535 | - | 239 | Protein_1694 | DUF1381 domain-containing protein | - |
| E3T04_RS08820 | 1746572..1747105 | - | 534 | WP_001061840.1 | dUTPase | - |
| E3T04_RS14845 | 1747123..1747281 | - | 159 | WP_000889681.1 | hypothetical protein | - |
| E3T04_RS08825 | 1747282..1747563 | - | 282 | WP_000454994.1 | hypothetical protein | - |
| E3T04_RS14850 | 1747564..1747737 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| E3T04_RS08830 | 1747727..1747978 | - | 252 | WP_001065110.1 | DUF1024 family protein | Toxin |
| E3T04_RS08835 | 1747993..1748241 | - | 249 | WP_001126839.1 | phi PVL orf 51-like protein | - |
| E3T04_RS08840 | 1748242..1748601 | - | 360 | WP_000029372.1 | hypothetical protein | - |
| E3T04_RS08845 | 1748729..1749034 | - | 306 | WP_000101252.1 | hypothetical protein | - |
| E3T04_RS08850 | 1749035..1749220 | - | 186 | WP_001187250.1 | DUF3113 family protein | - |
| E3T04_RS08855 | 1749225..1749629 | - | 405 | WP_000049786.1 | DUF1064 domain-containing protein | - |
| E3T04_RS08860 | 1749640..1749861 | - | 222 | WP_001123688.1 | DUF3269 family protein | - |
| E3T04_RS08865 | 1749874..1750032 | - | 159 | WP_000256597.1 | hypothetical protein | - |
| E3T04_RS08870 | 1750026..1750805 | - | 780 | WP_000803070.1 | ATP-binding protein | - |
| E3T04_RS08875 | 1750815..1751618 | - | 804 | WP_160200009.1 | phage replisome organizer N-terminal domain-containing protein | - |
| E3T04_RS08880 | 1751590..1752282 | - | 693 | WP_001644874.1 | hypothetical protein | - |
| E3T04_RS08885 | 1752295..1752846 | - | 552 | WP_000704705.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1715521..1760754 | 45233 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9405.32 Da Isoelectric Point: 3.8051
>T147628 WP_001065110.1 NZ_CP047782:c1747978-1747727 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T147628 NZ_CP063153:c2507445-2507342 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT147628 WP_000028424.1 NZ_CP047782:c1747737-1747564 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT147628 NZ_CP063153:2507304-2507575 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|