Detailed information of TA system TA147622

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 884991..885329
• Replicon: chromosome
• Accession: NZ_CP047782
• Organism: Staphylococcus aureus strain UP_1352

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3T04_RS04555
• Protein ID: WP_011447039.1
• Coordinates: 884991..885167 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	885155..885329 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T04_RS04535	880226..884011	+	3786	WP_160199975.1	hypothetical protein	-
E3T04_RS04540	884001..884153	+	153	WP_001153681.1	hypothetical protein	-
E3T04_RS04545	884200..884487	+	288	WP_001040261.1	hypothetical protein	-
E3T04_RS04550	884545..884841	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
E3T04_RS04555	884991..885167	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	885155..885329	-	175	-	-	Antitoxin
E3T04_RS04565	885379..885633	+	255	WP_000611512.1	phage holin	-
E3T04_RS04570	885645..886400	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3T04_RS04575	886591..887082	+	492	WP_000919350.1	staphylokinase	-
E3T04_RS04580	887732..888067	+	336	Protein_889	SH3 domain-containing protein	-
E3T04_RS04585	888162..888611	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3T04_RS04590	889297..889647	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3T04_RS04595	889700..889960	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hly/hla / sak / chp / scn / hly/hla / hly/hla	845965..897094	51129

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147622 WP_011447039.1 NZ_CP047782:884991-885167 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147622 NZ_CP063153:c1800188-1799694 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT147622 NZ_CP047782:c885329-885155 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin