Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2512968..2513485 Replicon chromosome
Accession NZ_CP047781
Organism Staphylococcus aureus strain UP_1452

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3T07_RS12560 Protein ID WP_000251928.1
Coordinates 2513219..2513485 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3T07_RS12555 Protein ID WP_000584497.1
Coordinates 2512968..2513219 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T07_RS12525 2508668..2509387 + 720 WP_000479573.1 amino acid ABC transporter permease -
E3T07_RS12530 2509384..2510115 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3T07_RS12535 2510212..2511462 - 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3T07_RS12540 2511717..2512079 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3T07_RS12545 2512098..2512697 + 600 WP_000162804.1 DsbA family protein -
E3T07_RS12550 2512704..2512804 + 101 Protein_2442 hypothetical protein -
E3T07_RS12555 2512968..2513219 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T07_RS12560 2513219..2513485 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3T07_RS12565 2513778..2515325 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T07_RS12570 2515511..2515978 + 468 WP_000153340.1 SRPBCC domain-containing protein -
E3T07_RS12575 2516064..2516246 + 183 WP_000079140.1 hypothetical protein -
E3T07_RS12580 2516449..2517273 + 825 WP_000594640.1 formate/nitrite transporter family protein -
E3T07_RS12585 2517741..2518277 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T147610 WP_000251928.1 NZ_CP047781:2513219-2513485 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147610 NZ_CP063150:c1345517-1344771 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATCTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATCGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT147610 WP_000584497.1 NZ_CP047781:2512968-2513219 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT147610 NZ_CP063150:c1344771-1344601 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References