Detailed information of TA system TA147608

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2488000..2488184
• Replicon: chromosome
• Accession: NZ_CP047781
• Organism: Staphylococcus aureus strain UP_1452

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T07_RS12425
• Protein ID: WP_000482647.1
• Coordinates: 2488000..2488107 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2488124..2488184 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T07_RS12400	2483362..2483835	+	474	WP_000456496.1	GyrI-like domain-containing protein	-
E3T07_RS12405	2483958..2485169	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3T07_RS12410	2485351..2486010	-	660	WP_000831298.1	membrane protein	-
E3T07_RS12415	2486070..2487212	-	1143	WP_001176855.1	glycerate kinase	-
E3T07_RS12420	2487480..2487866	+	387	WP_000779351.1	flippase GtxA	-
E3T07_RS12425	2488000..2488107	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2488124..2488184	-	61	-	-	Antitoxin
E3T07_RS12430	2488755..2490518	+	1764	WP_001064829.1	ABC transporter ATP-binding protein/permease	-
E3T07_RS12435	2490543..2492276	+	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
E3T07_RS12440	2492507..2492674	+	168	Protein_2420	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147608 WP_000482647.1 NZ_CP047781:2488000-2488107 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147608 NZ_CP063149:193707-194189 [Klebsiella pneumoniae]
GTGGGACGTTTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTGGCTGAGTTCGTCAGCGGTGAGGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCCCTCGGAGCTGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGCGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAGCGAACATTGTTTCTTAGACTCCCT
TAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147608 NZ_CP047781:c2488184-2488124 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin