Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 837977..838400 Replicon chromosome
Accession NZ_CP047781
Organism Staphylococcus aureus strain UP_1452

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag E3T07_RS04165 Protein ID WP_001065110.1
Coordinates 838149..838400 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag E3T07_RS04160 Protein ID WP_000028425.1
Coordinates 837977..838159 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T07_RS04120 833369..833659 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
E3T07_RS04125 833794..833898 + 105 WP_015978074.1 hypothetical protein -
E3T07_RS04130 834001..836448 - 2448 WP_000884879.1 virulence-associated E family protein -
E3T07_RS04135 836501..836701 - 201 WP_000265258.1 DUF1514 family protein -
E3T07_RS04140 836769..836921 - 153 WP_000595237.1 transcriptional activator RinB -
E3T07_RS04145 836914..837150 - 237 WP_000483477.1 hypothetical protein -
E3T07_RS04150 837175..837411 - 237 WP_000195806.1 DUF1381 domain-containing protein -
E3T07_RS04155 837448..837984 - 537 WP_000185703.1 dUTPase -
E3T07_RS04160 837977..838159 - 183 WP_000028425.1 hypothetical protein Antitoxin
E3T07_RS04165 838149..838400 - 252 WP_001065110.1 DUF1024 family protein Toxin
E3T07_RS04170 838415..838657 - 243 WP_000132193.1 hypothetical protein -
E3T07_RS04175 838672..838872 - 201 WP_000235324.1 hypothetical protein -
E3T07_RS04180 838875..839132 - 258 WP_000022730.1 DUF3310 domain-containing protein -
E3T07_RS04185 839132..839533 - 402 WP_000113974.1 PVL family protein -
E3T07_RS04190 839533..839718 - 186 WP_001164629.1 DUF3113 family protein -
E3T07_RS04195 839731..841683 - 1953 WP_160191378.1 DNA polymerase -
E3T07_RS04200 841751..842308 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ebp / gnd 755753..877672 121919


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T147599 WP_001065110.1 NZ_CP047781:c838400-838149 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T147599 NZ_CP063147:1981501-1981603 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT147599 WP_000028425.1 NZ_CP047781:c838159-837977 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT147599 NZ_CP063147:c1981610-1981465 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References