Detailed information of TA system TA147597

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 808842..809141
• Replicon: chromosome
• Accession: NZ_CP047781
• Organism: Staphylococcus aureus strain UP_1452

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3T07_RS03990
• Protein ID: WP_011447039.1
• Coordinates: 808965..809141 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	808842..808899 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T07_RS03955	804055..804963	-	909	WP_000476878.1	DUF1672 domain-containing protein	-
E3T07_RS03960	805021..805926	-	906	WP_000913238.1	DUF1672 domain-containing protein	-
E3T07_RS14940	806016..806231	-	216	WP_170267452.1	hypothetical protein	-
E3T07_RS03970	806479..807093	-	615	WP_000051376.1	hypothetical protein	-
E3T07_RS14945	807090..807266	-	177	WP_000201922.1	hypothetical protein	-
E3T07_RS03975	807732..808487	-	756	WP_000861038.1	CHAP domain-containing protein	-
E3T07_RS03980	808499..808753	-	255	WP_000611512.1	phage holin	-
E3T07_RS03985	808805..808912	+	108	WP_031790389.1	hypothetical protein	-
-	808834..808973	+	140	NuclAT_1	-	-
-	808834..808973	+	140	NuclAT_1	-	-
-	808834..808973	+	140	NuclAT_1	-	-
-	808834..808973	+	140	NuclAT_1	-	-
-	808842..808899	+	58	-	-	Antitoxin
E3T07_RS03990	808965..809141	-	177	WP_011447039.1	putative holin-like toxin	Toxin
E3T07_RS03995	809294..809593	-	300	WP_000466784.1	DUF2951 domain-containing protein	-
E3T07_RS04000	809639..809803	-	165	WP_000916020.1	XkdX family protein	-
E3T07_RS04005	809796..810185	-	390	WP_001166599.1	DUF2977 domain-containing protein	-
E3T07_RS04010	810185..811651	-	1467	WP_000067132.1	BppU family phage baseplate upper protein	-
E3T07_RS04015	811651..813561	-	1911	WP_000429558.1	minor structural protein	-
E3T07_RS04020	813577..813867	-	291	WP_000179858.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ebp / gnd	755753..877672	121919

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147597 WP_011447039.1 NZ_CP047781:c809141-808965 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147597 NZ_CP063147:739176-739661 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT147597 NZ_CP047781:808842-808899 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• PDB: 7NS1

Antitoxin