Detailed information of TA system TA147593

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20057..20395
• Replicon: chromosome
• Accession: NZ_CP047781
• Organism: Staphylococcus aureus strain UP_1452

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3T07_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20057..20233 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20221..20395 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T07_RS00085	17838..17990	+	153	WP_001153681.1	hypothetical protein	-
E3T07_RS00090	18037..18324	+	288	WP_001040259.1	hypothetical protein	-
E3T07_RS00095	18380..18754	+	375	WP_000340977.1	hypothetical protein	-
E3T07_RS00100	19175..19948	+	774	WP_000750406.1	staphylococcal enterotoxin type A	-
E3T07_RS00105	20057..20233	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	20221..20395	-	175	-	-	Antitoxin
E3T07_RS00115	20445..20699	+	255	WP_000611512.1	phage holin	-
E3T07_RS00120	20711..21466	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3T07_RS00125	21657..22148	+	492	WP_000919350.1	staphylokinase	-
E3T07_RS00130	22798..23133	+	336	Protein_26	SH3 domain-containing protein	-
E3T07_RS00135	23228..23677	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3T07_RS00140	24363..24713	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3T07_RS00145	24766..25026	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / chp / scn / hlb / map	1..47692	47691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147593 WP_011447039.1 NZ_CP047781:20057-20233 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147593 NZ_CP063145:c620207-619923 [Cruoricaptor ignavus]
ATGGAAGTTTCAAGATTTGACATTGCGGATTATCTGGACAGCAATGAAATGATTGCTGAATATCTGAATGTAGTTCTGGA
AGAAGGTGAGGATTCCGATGTTGTAATCGCTATTGGAAATGTGGCGAAAGCTATCGGAATGACGAAGATTGCGGAAGAAA
CCGGTATGAGCAGACCGAGTTTATACAAGGCTTTTTCTGACGGTGCAAAACCGCAGTTTTCTACGGTGATGAAAGTGCTG
AAAGCAGTTGGCGGGCAGATAAAAGTGGAACCGATTACCGCTTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT147593 NZ_CP047781:c20395-20221 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin