Detailed information of TA system TA147590

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2731143..2731722
• Replicon: chromosome
• Accession: NZ_CP047780
• Organism: Staphylococcus aureus strain UP_1539

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3T11_RS13415
• Protein ID: WP_001025401.1
• Coordinates: 2731143..2731388 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2731357..2731722 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T11_RS13370	2727392..2728006	+	615	WP_000191466.1	hypothetical protein	-
E3T11_RS13375	2728003..2728149	-	147	WP_001794606.1	hypothetical protein	-
E3T11_RS13380	2728186..2728368	-	183	WP_000705240.1	hypothetical protein	-
E3T11_RS13385	2728439..2729170	-	732	WP_000511090.1	XRE family transcriptional regulator	-
E3T11_RS13390	2729322..2729534	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
E3T11_RS13395	2729582..2730025	+	444	WP_000435357.1	hypothetical protein	-
E3T11_RS13610	2730040..2730189	+	150	WP_000771849.1	hypothetical protein	-
E3T11_RS13400	2730230..2730442	-	213	WP_000362644.1	hypothetical protein	-
E3T11_RS13405	2730512..2730709	+	198	WP_001148860.1	hypothetical protein	-
E3T11_RS13410	2730696..2731076	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
E3T11_RS13415	2731143..2731388	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3T11_RS13420	2731357..2731722	-	366	WP_001128433.1	hypothetical protein	Antitoxin
E3T11_RS13425	2731777..2731992	+	216	WP_160188158.1	hypothetical protein	-
E3T11_RS13430	2732017..2732280	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
E3T11_RS13435	2732293..2732454	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
E3T11_RS13440	2732533..2732856	+	324	WP_000175000.1	hypothetical protein	-
E3T11_RS13445	2732871..2733233	+	363	WP_000985986.1	hypothetical protein	-
E3T11_RS13450	2733230..2734396	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
E3T11_RS13455	2734422..2734979	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T147590 WP_001025401.1 NZ_CP047780:2731143-2731388 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T147590 NZ_CP063143:972440-972790 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
TATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT147590 NZ_CP047780:c2731722-2731357 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin