Detailed information of TA system TA147583

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2114322..2114584
• Replicon: chromosome
• Accession: NZ_CP047780
• Organism: Staphylococcus aureus strain UP_1539

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: E3T11_RS10150
• Protein ID: WP_001802298.1
• Coordinates: 2114322..2114426 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2114421..2114584 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T11_RS10135	2111118..2111900	+	783	WP_000908174.1	ABC transporter ATP-binding protein	-
E3T11_RS10140	2111968..2112825	+	858	WP_000370931.1	Cof-type HAD-IIB family hydrolase	-
E3T11_RS10145	2113484..2113642	-	159	WP_001792784.1	hypothetical protein	-
E3T11_RS10150	2114322..2114426	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2114421..2114584	-	164	-	-	Antitoxin
E3T11_RS10155	2115234..2116880	+	1647	WP_000277718.1	IS1182 family transposase	-
E3T11_RS10160	2116909..2118000	-	1092	WP_000495672.1	hypothetical protein	-
E3T11_RS10165	2118266..2119246	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
E3T11_RS10170	2119248..2119568	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2115234..2116880	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T147583 WP_001802298.1 NZ_CP047780:2114322-2114426 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T147583 NZ_CP063127:379063-379368 [Haemophilus influenzae]
ATGTTTAATTTAAAACGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATGCTCATAGTAAGAT
TCCTTCTAATTTATCTAAAGTATTGGCAAGAAAATTGGATATGATAAGTGCTGCGGAAGACATCAATGATTTACGTTCTC
CGCCAGCTAATCACTTAGAGTTGCTTGAACCAAAAGAAAATAAAATTTATTCCATTCGAGTAAATAAACAATATCGCCTA
ATTTTTAAATATGAGAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTATAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT147583 NZ_CP047780:c2114584-2114421 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin