Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1859335..1859852 Replicon chromosome
Accession NZ_CP047780
Organism Staphylococcus aureus strain UP_1539

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag E3T11_RS08830 Protein ID WP_000113262.1
Coordinates 1859586..1859852 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag E3T11_RS08825 Protein ID WP_000584499.1
Coordinates 1859335..1859586 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T11_RS08795 1855033..1855752 + 720 WP_000479576.1 amino acid ABC transporter permease -
E3T11_RS08800 1855749..1856480 + 732 WP_042909118.1 amino acid ABC transporter ATP-binding protein -
E3T11_RS08805 1856577..1857827 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
E3T11_RS08810 1858082..1858444 + 363 WP_000819843.1 DUF4467 domain-containing protein -
E3T11_RS08815 1858463..1859062 + 600 WP_000162810.1 DsbA family protein -
E3T11_RS08820 1859069..1859170 + 102 Protein_1732 hypothetical protein -
E3T11_RS08825 1859335..1859586 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T11_RS08830 1859586..1859852 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
E3T11_RS08835 1860146..1861696 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T11_RS08840 1861882..1862349 + 468 WP_000153344.1 SRPBCC domain-containing protein -
E3T11_RS08845 1862436..1862618 + 183 WP_000079142.1 hypothetical protein -
E3T11_RS08850 1862835..1863659 + 825 WP_000572040.1 formate/nitrite transporter family protein -
E3T11_RS08855 1863893..1864429 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T147582 WP_000113262.1 NZ_CP047780:1859586-1859852 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147582 NZ_CP063115:252-425 [Haemophilus parainfluenzae]
ATGAAGCAAAGCGAATTTTTAAGATGGCTAATTGAGAATGGTGTTAGGACCGAAGAAGGGACTAGACACACGAAATTGTA
CTACAACGGTAAGCAATCAACTTTACCGAGACACCCAGGAAAAGAAATTGGAACTGGGTTGGTTTGTAGAATCAAAAAAC
AATTAGGCATCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT147582 WP_000584499.1 NZ_CP047780:1859335-1859586 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT147582 NZ_CP063115:555-971 [Haemophilus parainfluenzae]
ATGTTTTATCCTGCGACATTTACGTTAGAGGAGCATGGCGGATATACAGTCTCATTTAGAGATATACCTGAAGCGTTAAC
TTGTGGCGATAATCTTAATGATGCTAAAGAGATGGCTCAAGATGCTTTAATTACCGCAATGGATTTTTATTTTGAAGATC
GTCGTAGTGTACCTATGCCTAGTAAACCACGAAAAGGCGAAGAGTTAGTTGAATTACCTGATAGCATTTTTGCTAAAGTT
CTCTTATTAAATGAGCTAGTTAAGCAAAATATAAGTAATGCTGATTTGGCGAGACGAATACTTGTTAAGCCGCAGGAAGT
TCAGCGAATTGTTGATTTATCTCACAATACTAAAATTGATACGTTAAGCAAAGCATTAAGCGCATTAGGTAAGCGCTTGG
TTCTTTCTGTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References