Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1802531..1803054 Replicon chromosome
Accession NZ_CP047780
Organism Staphylococcus aureus strain UP_1539

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag E3T11_RS08555 Protein ID WP_000074045.1
Coordinates 1802788..1803054 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag E3T11_RS08550 Protein ID WP_000587619.1
Coordinates 1802531..1802788 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T11_RS08525 1797611..1798804 + 1194 WP_000675406.1 MFS transporter -
E3T11_RS08530 1799028..1799777 - 750 WP_000072464.1 hypothetical protein -
E3T11_RS08535 1799972..1801549 + 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
E3T11_RS08540 1801717..1802172 - 456 WP_000732082.1 DUF1307 domain-containing protein -
E3T11_RS08545 1802231..1802425 + 195 WP_001790145.1 hypothetical protein -
E3T11_RS08550 1802531..1802788 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T11_RS08555 1802788..1803054 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
E3T11_RS08560 1803410..1804486 + 1077 WP_001076673.1 M42 family metallopeptidase -
E3T11_RS08565 1804734..1805396 + 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
E3T11_RS08570 1805389..1806165 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
E3T11_RS08575 1806561..1807748 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T147579 WP_000074045.1 NZ_CP047780:1802788-1803054 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T147579 NZ_CP063086:383239-383640 [Helicobacter cinaedi]
ATGGCAAAAATAATGCTTGATACAAATATATGTATTTATATTATCAATAATAAACCGCAATATATTAAAGATAGATTTTT
ACAATACAGAATAGGCGATATTGCTATAAGCTCTATCAGTGTAGCTGAATTATACTTTGGTGTAGAAAAATCTCAATATA
AAGAAGCAAATACAAATGCTCTTAATACATTCCTAACACACCTTAAAGTCATAGATTTCGCACATAAAGAGGCACTTACA
TATGCAAAAATTAGAGCAGATTTAGAATACAAAAAGTCTCTCATAGGTGCTATGGATATGCTTATTTCAGCGGTAGCTCT
TGCAAATGATTTAACACTTATTACAAATAACACAAAAGAATTTCAAAGAGTTAAGAATCTAAAAATAGAAAATTGGGTGT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT147579 WP_000587619.1 NZ_CP047780:1802531-1802788 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT147579 NZ_CP063086:383027-383251 [Helicobacter cinaedi]
ATGAAAGCAAAAGTATTTAAAAGTGGTAATTCACTTGCGATAAGATTGCCAAAGGCATTGAATCTTACTAAGGATTGCGA
GTTTAATATAAAACAAATAAATAATAACATTGTTTTAACGCCTGCTAACTCAAATTGGGATAGTCTATTTTCAGCAATAG
ATAGCTTTAAGGGCGAAATAAAGCGAGATGAACTTATATTGCAGGATAGAGAATGGCAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References