Detailed information of TA system TA147576

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2245887..2246071
• Replicon: chromosome
• Accession: NZ_CP047779
• Organism: Staphylococcus aureus strain UP_1559

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T12_RS11435
• Protein ID: WP_000482647.1
• Coordinates: 2245964..2246071 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2245887..2245947 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T12_RS11420	2241398..2241565	-	168	Protein_2204	hypothetical protein	-
E3T12_RS11425	2241796..2243529	-	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
E3T12_RS11430	2243554..2245317	-	1764	WP_001064829.1	ABC transporter ATP-binding protein/permease	-
-	2245887..2245947	+	61	-	-	Antitoxin
E3T12_RS11435	2245964..2246071	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
E3T12_RS11440	2246205..2246591	-	387	WP_000779351.1	flippase GtxA	-
E3T12_RS11445	2246859..2248001	+	1143	WP_001176855.1	glycerate kinase	-
E3T12_RS11450	2248061..2248720	+	660	WP_000831298.1	membrane protein	-
E3T12_RS11455	2248902..2250113	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3T12_RS11460	2250236..2250709	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147576 WP_000482647.1 NZ_CP047779:c2246071-2245964 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147576 NZ_CP063081:405558-405869 [Helicobacter cinaedi]
TTGAGGCAGTTTGAGATTTTTTGGATAGATTTAAATCTTACAAAAGGAGCGGAAATTTCTAAAAAAAGACCTTGTGTGAT
TATCTCACCCAATGAATTAAACTATTTACAAACAAGACTTGTCGCGCCTATTACTTCAAAGGGATTTGATGCTCCTTTTA
GAGTAAATTTTGAATTAGAGGGCAAAAAGTCTAGAATCCTGTGCGACCAAATTCGTTGTGTGAGTATAGATAGATTCTTA
AATAAAATTTGTGATTTAGAATCTAATAAGCAAGAGGCTTTAAAAAATATTCTCCTAGAGATGTTCGCTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147576 NZ_CP047779:2245887-2245947 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin