Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2220586..2221103 Replicon chromosome
Accession NZ_CP047779
Organism Staphylococcus aureus strain UP_1559

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag E3T12_RS11300 Protein ID WP_000251928.1
Coordinates 2220586..2220852 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag E3T12_RS11305 Protein ID WP_000584497.1
Coordinates 2220852..2221103 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T12_RS11275 2215794..2216330 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
E3T12_RS11280 2216798..2217622 - 825 WP_000594640.1 formate/nitrite transporter family protein -
E3T12_RS11285 2217825..2218007 - 183 WP_000079140.1 hypothetical protein -
E3T12_RS11290 2218093..2218560 - 468 WP_000153340.1 SRPBCC domain-containing protein -
E3T12_RS11295 2218746..2220293 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
E3T12_RS11300 2220586..2220852 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
E3T12_RS11305 2220852..2221103 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
E3T12_RS11310 2221267..2221367 - 101 Protein_2182 hypothetical protein -
E3T12_RS11315 2221374..2221973 - 600 WP_000162804.1 DsbA family protein -
E3T12_RS11320 2221992..2222354 - 363 WP_000819843.1 DUF4467 domain-containing protein -
E3T12_RS11325 2222609..2223859 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
E3T12_RS11330 2223956..2224687 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
E3T12_RS11335 2224684..2225403 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T147575 WP_000251928.1 NZ_CP047779:c2220852-2220586 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T147575 NZ_CP063073:3719752-3719934 [Pseudomonas poae]
GTGGATAGCCGATATTTGATAGGTCACATCGTTGCGGACGGCTGGTATCTGGTGCGCACCCGAGGCAGTCATCATCACTT
CAAGCACCCGACAAAACCGGGGCTGGTGACGATTCCTCATCCAAAGAAGGACCTGTTGGACAAGACTGCCAAGAGCATTT
TGAAACAGGCCCTGTTGAGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT147575 WP_000584497.1 NZ_CP047779:c2221103-2220852 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT147575 NZ_CP063073:3719957-3720367 [Pseudomonas poae]
ATGCTTTACCCCATCGCAATTTCAACCGGTGACGAGGACCACGCCTGGGGCGTGGAAGTCCCGGACATTCCCGGCTGCTA
CTCAGCTGGCGATGACCTGGACGAGGCCATGGCCATGGCCCGGGAGGCCATCGAGGGGCATTTCGAGATCCTCGCGGAAG
ATGGCGCGCCGATTCCCACGGCGCAAAAAGTTACCTTGCACGCAGCGAATCCCCAATACGCCGGCTGCACCTGGGCTGTG
GTGGACATTGATGTCACCAAATACCTGGGCAAAGCGCAGAAGCTCAACATTACCTTGCCGGGTTATCTGTTGAATCGCAT
CGATGAATATGTACTGAACCACCCGGAAGAAAAAAGCCGCTCGGGGTTTCTGGCGTCCGCCGCATTGAAAGTATTGCAAC
AGGACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References