147570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1805133..1805556 Replicon chromosome
Accession NZ_CP047779
Organism Staphylococcus aureus strain UP_1559

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag E3T12_RS09115 Protein ID WP_001065091.1
Coordinates 1805305..1805556 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag E3T12_RS09110 Protein ID WP_000028422.1
Coordinates 1805133..1805315 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T12_RS09065 1800519..1802180 - 1662 WP_000625088.1 terminase large subunit -
E3T12_RS09070 1802177..1802521 - 345 WP_000402904.1 hypothetical protein -
E3T12_RS09075 1802651..1802950 - 300 WP_000988336.1 HNH endonuclease -
E3T12_RS09080 1803182..1803598 - 417 WP_000590122.1 hypothetical protein -
E3T12_RS09085 1803626..1803826 - 201 WP_000265043.1 DUF1514 family protein -
E3T12_RS09090 1803826..1803975 - 150 WP_000595265.1 transcriptional activator RinB -
E3T12_RS09095 1803972..1804358 - 387 WP_000592207.1 hypothetical protein -
E3T12_RS09100 1804355..1804561 - 207 WP_000195803.1 DUF1381 domain-containing protein -
E3T12_RS09105 1804598..1805140 - 543 WP_000185659.1 dUTP pyrophosphatase -
E3T12_RS09110 1805133..1805315 - 183 WP_000028422.1 hypothetical protein Antitoxin
E3T12_RS09115 1805305..1805556 - 252 WP_001065091.1 DUF1024 family protein Toxin
E3T12_RS14480 1805549..1805716 - 168 WP_001624242.1 hypothetical protein -
E3T12_RS09120 1805728..1805970 - 243 WP_000131366.1 hypothetical protein -
E3T12_RS09125 1805974..1806342 - 369 WP_000101274.1 hypothetical protein -
E3T12_RS09130 1806355..1806664 - 310 Protein_1759 RusA family crossover junction endodeoxyribonuclease -
E3T12_RS09135 1806673..1806891 - 219 WP_000338531.1 hypothetical protein -
E3T12_RS09140 1806898..1807771 - 874 Protein_1761 DnaD domain protein -
E3T12_RS09145 1807801..1808271 - 471 WP_000934764.1 single-stranded DNA-binding protein -
E3T12_RS09150 1808272..1808889 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
E3T12_RS09155 1808970..1809890 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / sea / hlb / groEL 1777465..1833429 55964


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T147570 WP_001065091.1 NZ_CP047779:c1805556-1805305 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T147570 NZ_CP063060:c5211-4939 [Comamonas thiooxydans]
ATGGCCTGGAAGATTGAACTGTCTGAAGGCGCTGTCAAAAACCTCAAGCAGCTCGATCACCAACACGCCCGACGCATCCT
GAACTTTTTGCACAGTCGAGTGGCGCAACTTGATGACCCGCGCAGCATTGGCGAGGCACTCAAGGGCTCCAAGCTGGGGG
AGCTTTGGAAGTACCGTGTGGGGGACTACCGAATCATTGCTGACATTGAGGACAGCGTGATGCGGGTTTTGGTGTTGAAG
GTGGGAAACCGACGCGAGGTTTATCGCGGTTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT147570 WP_000028422.1 NZ_CP047779:c1805315-1805133 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT147570 NZ_CP063060:c5422-5195 [Comamonas thiooxydans]
ATGTCTGTATCTCTTCGCCTACCCCCAGAGCTGAACCAGCGTCTGAGCCTCTTGGCTGAGCAAACAGGCCGCTCTAAGAC
CTTCTACATGCTCGAAGCCATCAAGCAGCACCTGGATGACCTGGAGGACGTTTATTTGGCAGAGCGTGAGCTTGAAGCGG
TGCGTTCCGGTAAATCCAAGGCCGTGCCCTTGGAAGAAGTCATGAAGCAGTATGGCCTGGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References