Detailed information of TA system TA147567

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1781814..1782121
• Replicon: chromosome
• Accession: NZ_CP047779
• Organism: Staphylococcus aureus strain UP_1559

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3T12_RS08970
• Protein ID: WP_011447039.1
• Coordinates: 1781945..1782121 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1781814..1781953 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T12_RS08930	1777152..1777412	+	261	WP_001791826.1	hypothetical protein	-
E3T12_RS08935	1777465..1777815	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3T12_RS08940	1778501..1778950	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
E3T12_RS08945	1779045..1779380	-	336	Protein_1720	SH3 domain-containing protein	-
E3T12_RS08950	1780030..1780521	-	492	WP_000919350.1	staphylokinase	-
E3T12_RS08955	1780712..1781467	-	756	WP_000861038.1	CHAP domain-containing protein	-
E3T12_RS08960	1781479..1781733	-	255	WP_000611512.1	phage holin	-
E3T12_RS08965	1781785..1781892	+	108	WP_001791821.1	hypothetical protein	-
-	1781814..1781953	+	140	NuclAT_0	-	Antitoxin
-	1781814..1781953	+	140	NuclAT_0	-	Antitoxin
-	1781814..1781953	+	140	NuclAT_0	-	Antitoxin
-	1781814..1781953	+	140	NuclAT_0	-	Antitoxin
E3T12_RS08970	1781945..1782121	-	177	WP_011447039.1	putative holin-like toxin	Toxin
E3T12_RS08975	1782230..1783003	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
E3T12_RS08980	1783424..1783798	-	375	WP_000340977.1	hypothetical protein	-
E3T12_RS08985	1783854..1784141	-	288	WP_001040259.1	hypothetical protein	-
E3T12_RS08990	1784188..1784340	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sea / hlb / groEL	1777465..1833429	55964

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147567 WP_011447039.1 NZ_CP047779:c1782121-1781945 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147567 NZ_CP063057:c2751545-2751159 [Comamonas thiooxydans]
ATGCCGGTGTCCGTTCTAGTCGATACATCGGTGTGGGTGAGGCATTTTCGGGAGGCCGACATTCACCTGCAGGAGCTCCT
GTTGCAAGACAGCGTGCTGATGCATCCCATGGTGCATGCAGAGTTGGCCTGCGGCACGCCGCCAGCGCCGCGTGCCGATA
CGCTCGCAGCCCTGGCCATGCTGCGGCCGAGCCAGGAAGCTTCAATTCCCGAGACTTTGGCCTTCCTTGAGAAGAACAAG
CTATTCGGTAAGGGCTGCGGCTTGGTCGATCTATCGCTGCTCGCCTCGACGCTAATCACACCAGGCGCTTTGCTTTGGAC
TGCAGATCGACGCCTTGCTGAGTTGGCCGCTCAGCTTGGCGTGGCCTATGCCATACCAACGCATTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT147567 NZ_CP047779:1781814-1781953 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin