Detailed information of TA system TA147560

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19731..20069
• Replicon: chromosome
• Accession: NZ_CP047779
• Organism: Staphylococcus aureus strain UP_1559

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3T12_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 19731..19907 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19895..20069 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T12_RS00085	14966..18751	+	3786	WP_031783569.1	phage minor structural protein	-
E3T12_RS00090	18741..18893	+	153	WP_001153681.1	hypothetical protein	-
E3T12_RS00095	18940..19227	+	288	WP_001040254.1	hypothetical protein	-
E3T12_RS00100	19285..19581	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
E3T12_RS00105	19731..19907	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	19895..20069	-	175	-	-	Antitoxin
E3T12_RS00115	20119..20373	+	255	WP_000611512.1	phage holin	-
E3T12_RS00120	20385..21140	+	756	WP_000861038.1	CHAP domain-containing protein	-
E3T12_RS00125	22037..22864	-	828	WP_000136022.1	alpha/beta hydrolase	-
E3T12_RS00130	22922..24136	-	1215	WP_000286469.1	NADH-dependent flavin oxidoreductase	-
E3T12_RS00135	24232..24330	+	99	WP_001803958.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1..21140	21139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T147560 WP_011447039.1 NZ_CP047779:19731-19907 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T147560 NZ_CP063050:c178562-178302 [Photobacterium damselae subsp. damselae]
ATGATGATTAATTTCACGCCTAACGCTTGGGATGATTACTTATACTGGCAATCTCAAGATAAGAAGACTTTAAAACGAAT
CAATAAACTGATTGAGAATTGTGTTAGAACGCCGTTCGAAGGAATTGGAAAGCCTGAACCATTGAAAGATAACTTATCAG
GCTATTGGTCGCGACGCATTGATGATACACATAGATTAGTCTATAAAGCCACTCAAAATACCTTAGTCATTGTAGCTGTG
CGGTTTCACTACCAAAAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT147560 NZ_CP047779:c20069-19895 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin