Detailed information of TA system TA147551

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2398265..2398449
• Replicon: chromosome
• Accession: NZ_CP047778
• Organism: Staphylococcus aureus strain UP_1572

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T13_RS11660
• Protein ID: WP_000482647.1
• Coordinates: 2398265..2398372 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2398389..2398449 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T13_RS11635	2393627..2394100	+	474	WP_000456496.1	GyrI-like domain-containing protein	-
E3T13_RS11640	2394223..2395434	-	1212	WP_001191919.1	multidrug effflux MFS transporter	-
E3T13_RS11645	2395616..2396275	-	660	WP_160187083.1	hypothetical protein	-
E3T13_RS11650	2396335..2397477	-	1143	WP_001176855.1	glycerate kinase	-
E3T13_RS11655	2397745..2398131	+	387	WP_000779351.1	flippase GtxA	-
E3T13_RS11660	2398265..2398372	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2398389..2398449	-	61	-	-	Antitoxin
E3T13_RS11665	2399020..2400783	+	1764	WP_160187084.1	ABC transporter ATP-binding protein/permease	-
E3T13_RS11670	2400808..2402541	+	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
E3T13_RS11675	2402772..2402939	+	168	Protein_2266	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T147551 WP_000482647.1 NZ_CP047778:2398265-2398372 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T147551 NZ_CP063046:c4700028-4699921 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT147551 NZ_CP047778:c2398449-2398389 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin