Detailed information of TA system TA147543

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 221865..222045
• Replicon: chromosome
• Accession: NZ_CP047778
• Organism: Staphylococcus aureus strain UP_1572

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: E3T13_RS01370
• Protein ID: WP_001801861.1
• Coordinates: 221950..222045 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	221865..221922 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T13_RS01345	217278..219698	-	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-
E3T13_RS01350	220223..220665	+	443	Protein_236	DUF1433 domain-containing protein	-
E3T13_RS01355	220665..221108	+	444	WP_000731421.1	DUF1433 domain-containing protein	-
E3T13_RS01360	221108..221551	+	444	WP_001037039.1	DUF1433 domain-containing protein	-
E3T13_RS01365	221726..221827	-	102	WP_001791232.1	hypothetical protein	-
-	221865..221922	+	58	-	-	Antitoxin
E3T13_RS01370	221950..222045	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
E3T13_RS01375	222496..222942	+	447	WP_000747804.1	DUF1433 domain-containing protein	-
E3T13_RS01380	223135..223704	+	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
E3T13_RS01385	223704..225071	+	1368	WP_001093574.1	FRG domain-containing protein	-
E3T13_RS01390	225220..225792	-	573	WP_000414222.1	hypothetical protein	-
E3T13_RS01395	225890..226234	-	345	WP_000627550.1	DUF3969 family protein	-
E3T13_RS01400	226275..226901	-	627	WP_000669038.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T147543 WP_001801861.1 NZ_CP047778:c222045-221950 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T147543 NZ_CP063046:c1699131-1698958 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT147543 NZ_CP047778:221865-221922 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin