147530

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2368898..2369082 Replicon chromosome
Accession NZ_CP047777
Organism Staphylococcus aureus strain UP_1632

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag E3T16_RS11725 Protein ID WP_000482652.1
Coordinates 2368898..2369005 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2369022..2369082 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T16_RS11700 2364260..2364733 + 474 WP_000456486.1 GyrI-like domain-containing protein -
E3T16_RS11705 2364856..2366067 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
E3T16_RS11710 2366249..2366908 - 660 WP_000831298.1 membrane protein -
E3T16_RS11715 2366968..2368110 - 1143 WP_001176863.1 glycerate kinase -
E3T16_RS11720 2368378..2368764 + 387 WP_000779360.1 flippase GtxA -
E3T16_RS11725 2368898..2369005 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2369022..2369082 - 61 - - Antitoxin
E3T16_RS11730 2369708..2371471 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
E3T16_RS11735 2371496..2373229 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
E3T16_RS11740 2373460..2373627 + 168 Protein_2271 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T147530 WP_000482652.1 NZ_CP047777:2368898-2369005 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T147530 NZ_CP063023:1903910-1904012 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT147530 NZ_CP047777:c2369082-2369022 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References