Detailed information of TA system TA147525

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1731283..1731862
• Replicon: chromosome
• Accession: NZ_CP047777
• Organism: Staphylococcus aureus strain UP_1632

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3T16_RS08815
• Protein ID: WP_001025401.1
• Coordinates: 1731617..1731862 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1731283..1731648 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T16_RS08775	1728026..1728583	-	558	WP_000645042.1	DUF2815 family protein	-
E3T16_RS08780	1728609..1729775	-	1167	WP_000762534.1	DUF2800 domain-containing protein	-
E3T16_RS08785	1729772..1730134	-	363	WP_000985976.1	hypothetical protein	-
E3T16_RS08790	1730149..1730472	-	324	WP_000174994.1	hypothetical protein	-
E3T16_RS08795	1730551..1730712	-	162	WP_001285963.1	DUF1270 family protein	-
E3T16_RS08800	1730725..1730988	-	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
E3T16_RS08805	1731013..1731228	-	216	WP_001036302.1	hypothetical protein	-
E3T16_RS08810	1731283..1731648	+	366	WP_001128433.1	hypothetical protein	Antitoxin
E3T16_RS08815	1731617..1731862	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3T16_RS08820	1731918..1732127	+	210	WP_000642492.1	hypothetical protein	-
E3T16_RS08825	1732117..1732260	-	144	WP_000939498.1	hypothetical protein	-
E3T16_RS08830	1732275..1732718	-	444	WP_023487065.1	hypothetical protein	-
E3T16_RS08835	1732731..1732979	-	249	WP_000272859.1	helix-turn-helix domain-containing protein	-
E3T16_RS08840	1733143..1733466	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	-
E3T16_RS08845	1733479..1733940	+	462	WP_031807889.1	toxin	-
E3T16_RS08850	1733958..1734542	+	585	WP_000825948.1	hypothetical protein	-
E3T16_RS08855	1734772..1734918	+	147	WP_001013104.1	hypothetical protein	-
E3T16_RS08860	1734915..1735529	-	615	WP_000191459.1	hypothetical protein	-
E3T16_RS08865	1735655..1736860	+	1206	WP_031795352.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1691677..1751717	60040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T147525 WP_001025401.1 NZ_CP047777:c1731862-1731617 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T147525 NZ_CP063019:c5419306-5418923 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT147525 NZ_CP047777:1731283-1731648 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin