Detailed information of TA system TA147524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1723773..1724196
• Replicon: chromosome
• Accession: NZ_CP047777
• Organism: Staphylococcus aureus strain UP_1632

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: E3T16_RS08735
• Protein ID: WP_031766094.1
• Coordinates: 1723945..1724196 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E3T16_RS08730
• Protein ID: WP_000028421.1
• Coordinates: 1723773..1723955 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T16_RS08685	1719073..1719363	-	291	WP_000665204.1	VRR-NUC domain-containing protein	-
E3T16_RS08690	1719497..1719601	+	105	WP_015978074.1	hypothetical protein	-
E3T16_RS14095	1719704..1722151	-	2448	WP_031765980.1	virulence-associated E family protein	-
E3T16_RS08700	1722203..1722403	-	201	WP_000265258.1	DUF1514 family protein	-
E3T16_RS08705	1722471..1722623	-	153	WP_031767608.1	transcriptional activator RinB	-
E3T16_RS08710	1722616..1722819	-	204	WP_001072794.1	hypothetical protein	-
E3T16_RS08715	1722816..1723010	-	195	WP_000132920.1	hypothetical protein	-
E3T16_RS08720	1723007..1723213	-	207	WP_000195785.1	DUF1381 domain-containing protein	-
E3T16_RS08725	1723250..1723780	-	531	WP_000185651.1	dUTP pyrophosphatase	-
E3T16_RS08730	1723773..1723955	-	183	WP_000028421.1	hypothetical protein	Antitoxin
E3T16_RS08735	1723945..1724196	-	252	WP_031766094.1	DUF1024 family protein	Toxin
E3T16_RS08740	1724189..1724497	-	309	WP_031895322.1	hypothetical protein	-
E3T16_RS08745	1724494..1724841	-	348	WP_000979209.1	hypothetical protein	-
E3T16_RS08750	1724906..1725154	-	249	WP_111023884.1	phi PVL orf 51-like protein	-
E3T16_RS08755	1725154..1725408	-	255	WP_000111487.1	DUF3310 domain-containing protein	-
E3T16_RS08760	1725408..1725807	-	400	Protein_1680	PVL family protein	-
E3T16_RS08765	1725807..1725992	-	186	WP_001164629.1	DUF3113 family protein	-
E3T16_RS08770	1726005..1727957	-	1953	WP_001796208.1	DNA polymerase	-
E3T16_RS08775	1728026..1728583	-	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1691677..1751717	60040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9393.31 Da
• Isoelectric Point: 4.0362

>T147524 WP_031766094.1 NZ_CP047777:c1724196-1723945 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEH

Nucleotide

• Length: 252 bp

>T147524 NZ_CP063019:c5068232-5067315 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6683.59 Da
• Isoelectric Point: 4.3791

>AT147524 WP_000028421.1 NZ_CP047777:c1723955-1723773 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Nucleotide

• Length: 183 bp

>AT147524 NZ_CP063019:c5068996-5068238 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA