Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1723773..1724196 Replicon chromosome
Accession NZ_CP047777
Organism Staphylococcus aureus strain UP_1632

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3T16_RS08735 Protein ID WP_031766094.1
Coordinates 1723945..1724196 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E3T16_RS08730 Protein ID WP_000028421.1
Coordinates 1723773..1723955 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T16_RS08685 1719073..1719363 - 291 WP_000665204.1 VRR-NUC domain-containing protein -
E3T16_RS08690 1719497..1719601 + 105 WP_015978074.1 hypothetical protein -
E3T16_RS14095 1719704..1722151 - 2448 WP_031765980.1 virulence-associated E family protein -
E3T16_RS08700 1722203..1722403 - 201 WP_000265258.1 DUF1514 family protein -
E3T16_RS08705 1722471..1722623 - 153 WP_031767608.1 transcriptional activator RinB -
E3T16_RS08710 1722616..1722819 - 204 WP_001072794.1 hypothetical protein -
E3T16_RS08715 1722816..1723010 - 195 WP_000132920.1 hypothetical protein -
E3T16_RS08720 1723007..1723213 - 207 WP_000195785.1 DUF1381 domain-containing protein -
E3T16_RS08725 1723250..1723780 - 531 WP_000185651.1 dUTP pyrophosphatase -
E3T16_RS08730 1723773..1723955 - 183 WP_000028421.1 hypothetical protein Antitoxin
E3T16_RS08735 1723945..1724196 - 252 WP_031766094.1 DUF1024 family protein Toxin
E3T16_RS08740 1724189..1724497 - 309 WP_031895322.1 hypothetical protein -
E3T16_RS08745 1724494..1724841 - 348 WP_000979209.1 hypothetical protein -
E3T16_RS08750 1724906..1725154 - 249 WP_111023884.1 phi PVL orf 51-like protein -
E3T16_RS08755 1725154..1725408 - 255 WP_000111487.1 DUF3310 domain-containing protein -
E3T16_RS08760 1725408..1725807 - 400 Protein_1680 PVL family protein -
E3T16_RS08765 1725807..1725992 - 186 WP_001164629.1 DUF3113 family protein -
E3T16_RS08770 1726005..1727957 - 1953 WP_001796208.1 DNA polymerase -
E3T16_RS08775 1728026..1728583 - 558 WP_000645042.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - geh 1691677..1751717 60040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9393.31 Da        Isoelectric Point: 4.0362

>T147524 WP_031766094.1 NZ_CP047777:c1724196-1723945 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T147524 NZ_CP063019:c5068232-5067315 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6683.59 Da        Isoelectric Point: 4.3791

>AT147524 WP_000028421.1 NZ_CP047777:c1723955-1723773 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND

Download         Length: 183 bp

>AT147524 NZ_CP063019:c5068996-5068238 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References