Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3494309..3494966 Replicon chromosome
Accession NZ_CP047765
Organism Enterobacter hormaechei strain Eho-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GVI62_RS16750 Protein ID WP_032609983.1
Coordinates 3494309..3494608 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GVI62_RS16755 Protein ID WP_032609984.1
Coordinates 3494619..3494966 (+) Length 116 a.a.

Genomic Context

GVI62_RS16740GVI62_RS16745GVI62_RS16750GVI62_RS16755GVI62_RS16770GVI62_RS16760GVI62_RS16765GVI62_RS16775GVI62_RS16780
Location: 3490686..3492878 (2193 bp)
Type: Others
Protein ID: Protein_3268
Location: 3492898..3494058 (1161 bp)
Type: Others
Protein ID: WP_087920848.1
Location: 3494309..3494608 (300 bp)
Type: Toxin
Protein ID: WP_032609983.1
Location: 3494619..3494966 (348 bp)
Type: Antitoxin
Protein ID: WP_032609984.1
Location: 3497229..3497831 (603 bp)
Type: Others
Protein ID: WP_032660049.1
Location: 3495042..3496223 (1182 bp)
Type: Others
Protein ID: WP_060580210.1
Location: 3496244..3497131 (888 bp)
Type: Others
Protein ID: WP_032660046.1
Location: 3497828..3498559 (732 bp)
Type: Others
Protein ID: WP_032660054.1
Location: 3498634..3499632 (999 bp)
Type: Others
Protein ID: WP_045346167.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GVI62_RS167403490686..3492878+2193Protein_3268type I secretion system permease/ATPase-
GVI62_RS167453492898..3494058+1161WP_087920848.1HlyD family efflux transporter periplasmic adaptor subunit-
GVI62_RS167503494309..3494608+300WP_032609983.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GVI62_RS167553494619..3494966+348WP_032609984.1HigA family addiction module antidote proteinAntitoxin
GVI62_RS167603495042..3496223-1182WP_060580210.1PLP-dependent aminotransferase family protein-
GVI62_RS167653496244..3497131-888WP_032660046.1LysR family transcriptional regulator-
GVI62_RS167703497229..3497831+603WP_032660049.1short chain dehydrogenase-
GVI62_RS167753497828..3498559-732WP_032660054.1class I SAM-dependent methyltransferase-
GVI62_RS167803498634..3499632-999WP_045346167.1transketolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T147511 WP_032609983.1 NZ_CP047765:3494309-3494608 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T147511 NZ_CP063011:c4853415-4853131 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT147511 WP_032609984.1 NZ_CP047765:3494619-3494966 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT147511 NZ_CP063011:c4853647-4853405 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References