Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3494309..3494966 Replicon chromosome
Accession NZ_CP047765
Organism Enterobacter hormaechei strain Eho-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GVI62_RS16750 Protein ID WP_032609983.1
Coordinates 3494309..3494608 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GVI62_RS16755 Protein ID WP_032609984.1
Coordinates 3494619..3494966 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI62_RS16740 3490686..3492878 + 2193 Protein_3268 type I secretion system permease/ATPase -
GVI62_RS16745 3492898..3494058 + 1161 WP_087920848.1 HlyD family efflux transporter periplasmic adaptor subunit -
GVI62_RS16750 3494309..3494608 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GVI62_RS16755 3494619..3494966 + 348 WP_032609984.1 HigA family addiction module antidote protein Antitoxin
GVI62_RS16760 3495042..3496223 - 1182 WP_060580210.1 PLP-dependent aminotransferase family protein -
GVI62_RS16765 3496244..3497131 - 888 WP_032660046.1 LysR family transcriptional regulator -
GVI62_RS16770 3497229..3497831 + 603 WP_032660049.1 short chain dehydrogenase -
GVI62_RS16775 3497828..3498559 - 732 WP_032660054.1 class I SAM-dependent methyltransferase -
GVI62_RS16780 3498634..3499632 - 999 WP_045346167.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T147511 WP_032609983.1 NZ_CP047765:3494309-3494608 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T147511 NZ_CP063011:c4853415-4853131 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT147511 WP_032609984.1 NZ_CP047765:3494619-3494966 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT147511 NZ_CP063011:c4853647-4853405 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References