Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1861385..1861887 Replicon chromosome
Accession NZ_CP047710
Organism Escherichia coli strain Eco-15

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag GVI77_RS08670 Protein ID WP_000767822.1
Coordinates 1861633..1861887 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag GVI77_RS08665 Protein ID WP_001259255.1
Coordinates 1861385..1861636 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI77_RS08640 1856563..1857630 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
GVI77_RS08645 1857630..1858700 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
GVI77_RS08650 1858697..1860001 - 1305 WP_001546022.1 histidinol dehydrogenase -
GVI77_RS08655 1860007..1860906 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
GVI77_RS08660 1861052..1861102 - 51 WP_001364200.1 his operon leader peptide -
GVI77_RS08665 1861385..1861636 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
GVI77_RS08670 1861633..1861887 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
GVI77_RS08675 1861970..1862794 + 825 WP_000754737.1 SDR family oxidoreductase -
GVI77_RS08680 1862840..1863769 + 930 WP_000803366.1 LysR family transcriptional regulator -
GVI77_RS08685 1863984..1864046 + 63 WP_010723108.1 membrane protein YoeI -
GVI77_RS08690 1864036..1865394 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T147390 WP_000767822.1 NZ_CP047710:1861633-1861887 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T147390 NZ_CP062945:366956-367210 [Bifidobacterium longum subsp. longum]
ATGCTGCTCTGCTGGACCGATGACGCCTGGGCCGACTACCTGTACTGGCAATCCCAGGACCGGAAGACCCTCAAACGCAT
CAACGCGCTCATACGGGACATGCAGCGGACCCCGTTCGAGGGTATCGGCAAGCCCGAACCCCTCAGATGTGGCCTGTCCG
GTGCATGGTCGCGGCGCATCGACTCAGCCAACCGCATCATCTACACCGTTGCCGACGACAGGCTCTGCATCCTCTCCGCG
AAGGACCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT147390 WP_001259255.1 NZ_CP047710:1861385-1861636 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT147390 NZ_CP062945:366690-366956 [Bifidobacterium longum subsp. longum]
ATGACACAGGCCGTGGCCTACAGCAATTTCAGGGCGAATCTCAAAACCTATATGCGCAGGGTCAACGAGGACGCCGACAC
CCTTCTCGTGACCAACGCGGACCCGGAGGACAACGTGGTCGTCATGAGCGCCGACGACTACGATTCGCTCATGGAGACGC
TGCGCGTCTACCAGAACCCGTATCTGAGCGATAAGGTGACGCGCGGCATGGCGCAGGTACGGCAGGGCCAGACGATGGCC
CGCGACCTTGTCGAAGCGGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References