Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 604026..604825 Replicon chromosome
Accession NZ_CP047710
Organism Escherichia coli strain Eco-15

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag GVI77_RS02940 Protein ID WP_000347251.1
Coordinates 604026..604490 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag GVI77_RS02945 Protein ID WP_001296435.1
Coordinates 604490..604825 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GVI77_RS02910 599027..599461 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
GVI77_RS02915 599479..600357 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
GVI77_RS02920 600347..601126 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
GVI77_RS02925 601137..601610 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
GVI77_RS02930 601633..602913 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
GVI77_RS02935 603162..603971 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
GVI77_RS02940 604026..604490 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
GVI77_RS02945 604490..604825 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
GVI77_RS02950 604974..606545 - 1572 WP_001273763.1 galactarate dehydratase -
GVI77_RS02955 606920..608254 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
GVI77_RS02960 608270..609040 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T147386 WP_000347251.1 NZ_CP047710:c604490-604026 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T147386 NZ_CP062940:c35502-35167 [Bifidobacterium longum subsp. longum]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAGCTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTACTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTTGGGCAAATAGCGGGTTTACATCCTGCTTTGAACCA
GCCGACGGCGATTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT147386 WP_001296435.1 NZ_CP047710:c604825-604490 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT147386 NZ_CP062940:c35775-35506 [Bifidobacterium longum subsp. longum]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAAGCGCATTCCCCTAAACCTTTCCTATACGA
TCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References