Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 185752..187070 | Replicon | chromosome |
| Accession | NZ_CP047710 | ||
| Organism | Escherichia coli strain Eco-15 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | F4T5A3 |
| Locus tag | GVI77_RS00870 | Protein ID | WP_001262467.1 |
| Coordinates | 186063..187070 (+) | Length | 336 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | F4T5A4 |
| Locus tag | GVI77_RS00865 | Protein ID | WP_001312177.1 |
| Coordinates | 185752..186063 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GVI77_RS00840 | 181284..182303 | + | 1020 | WP_000938855.1 | dipeptide ABC transporter permease DppB | - |
| GVI77_RS00845 | 182313..183215 | + | 903 | WP_000084677.1 | dipeptide ABC transporter permease DppC | - |
| GVI77_RS00850 | 183226..184209 | + | 984 | WP_001196477.1 | dipeptide ABC transporter ATP-binding protein | - |
| GVI77_RS00855 | 184206..185219 | + | 1014 | WP_000103572.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
| GVI77_RS00860 | 185444..185767 | + | 324 | WP_000563102.1 | helix-turn-helix transcriptional regulator | - |
| GVI77_RS00865 | 185752..186063 | + | 312 | WP_001312177.1 | HipA N-terminal domain-containing protein | Antitoxin |
| GVI77_RS00870 | 186063..187070 | + | 1008 | WP_001262467.1 | HipA domain-containing protein | Toxin |
| GVI77_RS00875 | 187087..188358 | - | 1272 | WP_001545666.1 | amino acid permease | - |
| - | 188720..188785 | - | 66 | NuclAT_27 | - | - |
| - | 188720..188785 | - | 66 | NuclAT_27 | - | - |
| - | 188720..188785 | - | 66 | NuclAT_27 | - | - |
| - | 188720..188785 | - | 66 | NuclAT_27 | - | - |
| GVI77_RS00880 | 188834..188941 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| - | 189203..189260 | - | 58 | NuclAT_26 | - | - |
| - | 189203..189260 | - | 58 | NuclAT_26 | - | - |
| - | 189203..189260 | - | 58 | NuclAT_26 | - | - |
| - | 189203..189260 | - | 58 | NuclAT_26 | - | - |
| GVI77_RS00885 | 189317..189424 | + | 108 | WP_000170748.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| GVI77_RS00890 | 189800..189907 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| GVI77_RS00895 | 189993..191672 | - | 1680 | Protein_176 | cellulose biosynthesis protein BcsG | - |
| GVI77_RS00900 | 191669..191860 | - | 192 | WP_000988308.1 | cellulose biosynthesis protein BcsF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 336 a.a. Molecular weight: 38320.60 Da Isoelectric Point: 5.5965
>T147384 WP_001262467.1 NZ_CP047710:186063-187070 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
Download Length: 1008 bp
>T147384 NZ_CP062939:c1650441-1650184 [Bifidobacterium subtile]
ATGATTATTGCGTGGACGCAGGATGCGTGGGATGACTACCTGTTTTGGCAGTCGCAGGATCGCAAGACGCTCAAACGAAT
CAACAGGCTCATCAACGACATGTGCAACCATCCATTCGAAGGCATCGGCAAGCCGGAGGCACTGCGATGGGGGCTGCAAG
GTGCATGGTCCCGGCGTATCGATTCGGCGAATCGCATTGTGTACACGGTTGTTGAAGGGCGGTTGTGCATTATTTCCGCG
CGGGACCATTATGAGTAG
ATGATTATTGCGTGGACGCAGGATGCGTGGGATGACTACCTGTTTTGGCAGTCGCAGGATCGCAAGACGCTCAAACGAAT
CAACAGGCTCATCAACGACATGTGCAACCATCCATTCGAAGGCATCGGCAAGCCGGAGGCACTGCGATGGGGGCTGCAAG
GTGCATGGTCCCGGCGTATCGATTCGGCGAATCGCATTGTGTACACGGTTGTTGAAGGGCGGTTGTGCATTATTTCCGCG
CGGGACCATTATGAGTAG
Antitoxin
Download Length: 104 a.a. Molecular weight: 11821.47 Da Isoelectric Point: 6.0609
>AT147384 WP_001312177.1 NZ_CP047710:185752-186063 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
Download Length: 312 bp
>AT147384 NZ_CP062939:c1650719-1650438 [Bifidobacterium subtile]
ATGGTGCAGGCGGTCGCATACAGCAATTTCCGCAAGGATCTCAAATCGTATATGCGCAAGGTCAATGAGGATTCGGACAT
GCTGCTCGTGACCAATACGAATCCGGATGACGACGTCGTGGTGATGAGCGCCGCCGATTACGACTCGATGATGGAGACGC
TGCGCGTCTATCAGAATCCCTACTTGCGCAACAAGATTACGCATGGACTTGAGCAGGTGCATCAGGGGCGGGTGCAGGAG
CATGCATTGTTCGATGATGATGGTTCCGGAGCGGCGGCATGA
ATGGTGCAGGCGGTCGCATACAGCAATTTCCGCAAGGATCTCAAATCGTATATGCGCAAGGTCAATGAGGATTCGGACAT
GCTGCTCGTGACCAATACGAATCCGGATGACGACGTCGTGGTGATGAGCGCCGCCGATTACGACTCGATGATGGAGACGC
TGCGCGTCTATCAGAATCCCTACTTGCGCAACAAGATTACGCATGGACTTGAGCAGGTGCATCAGGGGCGGGTGCAGGAG
CATGCATTGTTCGATGATGATGGTTCCGGAGCGGCGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3K2ZTB5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L3HKE2 |