Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3571029..3571689 Replicon chromosome
Accession NZ_CP047688
Organism Serratia marcescens strain 1140-

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GV224_RS17045 Protein ID WP_047571347.1
Coordinates 3571336..3571689 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag GV224_RS17040 Protein ID WP_033635213.1
Coordinates 3571029..3571331 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GV224_RS17035 3567824..3570766 + 2943 WP_052133530.1 salicylate synthase -
GV224_RS17040 3571029..3571331 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
GV224_RS17045 3571336..3571689 - 354 WP_047571347.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GV224_RS17050 3572129..3573424 + 1296 WP_047571345.1 MFS transporter -
GV224_RS17055 3573452..3574258 + 807 WP_043147694.1 substrate-binding domain-containing protein -
GV224_RS17060 3574233..3575132 - 900 WP_047571342.1 LysR family transcriptional regulator -
GV224_RS17065 3575225..3575590 - 366 WP_033635218.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13601.51 Da        Isoelectric Point: 9.4805

>T147291 WP_047571347.1 NZ_CP047688:c3571689-3571336 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPRLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTNWLNTLNEKE

Download         Length: 354 bp

>T147291 NZ_CP062900:c78746-78540 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATACCCTTATCGG
GGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT147291 WP_033635213.1 NZ_CP047688:c3571331-3571029 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT147291 NZ_CP062900:78733-78794 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References