Detailed information of TA system TA147269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3570697..3571357
• Replicon: chromosome
• Accession: NZ_CP047685
• Organism: Serratia marcescens strain 2838

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GV198_RS17030
• Protein ID: WP_047571347.1
• Coordinates: 3571004..3571357 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2V4GQ69
• Locus tag: GV198_RS17025
• Protein ID: WP_033635213.1
• Coordinates: 3570697..3570999 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV198_RS17020	3567489..3570434	+	2946	WP_201751704.1	salicylate synthase	-
GV198_RS17025	3570697..3570999	-	303	WP_033635213.1	XRE family transcriptional regulator	Antitoxin
GV198_RS17030	3571004..3571357	-	354	WP_047571347.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GV198_RS17035	3571797..3573092	+	1296	WP_047571345.1	MFS transporter	-
GV198_RS17040	3573120..3573926	+	807	WP_043147694.1	substrate-binding domain-containing protein	-
GV198_RS17045	3573901..3574800	-	900	WP_047571342.1	LysR family transcriptional regulator	-
GV198_RS17050	3574893..3575258	-	366	WP_033635218.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3559451..3580282	20831

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13601.51 Da
• Isoelectric Point: 9.4805

>T147269 WP_047571347.1 NZ_CP047685:c3571357-3571004 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPRLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTNWLNTLNEKE

Nucleotide

• Length: 354 bp

>T147269 NZ_CP062895:661002-661316 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11079.94 Da
• Isoelectric Point: 6.4738

>AT147269 WP_033635213.1 NZ_CP047685:c3570999-3570697 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT147269 NZ_CP062895:661313-661729 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A2V4GQ69