Detailed information of TA system TA147241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2105876..2106536
• Replicon: chromosome
• Accession: NZ_CP047682
• Organism: Serratia marcescens strain 3024

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GV218_RS09890
• Protein ID: WP_047571347.1
• Coordinates: 2105876..2106229 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2V4GQ69
• Locus tag: GV218_RS09895
• Protein ID: WP_033635213.1
• Coordinates: 2106234..2106536 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GV218_RS09870	2101975..2102340	+	366	WP_033635218.1	diacylglycerol kinase	-
GV218_RS09875	2102433..2103332	+	900	WP_047571342.1	LysR family transcriptional regulator	-
GV218_RS09880	2103307..2104113	-	807	WP_043147694.1	substrate-binding domain-containing protein	-
GV218_RS09885	2104141..2105436	-	1296	WP_047571345.1	MFS transporter	-
GV218_RS09890	2105876..2106229	+	354	WP_047571347.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GV218_RS09895	2106234..2106536	+	303	WP_033635213.1	XRE family transcriptional regulator	Antitoxin
GV218_RS09900	2106799..2109741	-	2943	WP_052133530.1	salicylate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13601.51 Da
• Isoelectric Point: 9.4805

>T147241 WP_047571347.1 NZ_CP047682:2105876-2106229 [Serratia marcescens]
VWEIKTTDAFDNWFSSLHDADRAGVLAALMILREKGPRLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMLQIADREFTNWLNTLNEKE

Nucleotide

• Length: 354 bp

>T147241 NZ_CP062889:1004311-1004646 [Escherichia coli O100:H21]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11079.94 Da
• Isoelectric Point: 6.4738

>AT147241 WP_033635213.1 NZ_CP047682:2106234-2106536 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT147241 NZ_CP062889:1004063-1004311 [Escherichia coli O100:H21]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2V4GQ69