Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3887830..3888523 Replicon chromosome
Accession NZ_CP047662
Organism Escherichia coli strain LD93-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GUU84_RS18455 Protein ID WP_000415584.1
Coordinates 3888227..3888523 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GUU84_RS18450 Protein ID WP_000650107.1
Coordinates 3887830..3888225 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU84_RS18440 3883694..3885952 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
GUU84_RS18445 3886090..3887697 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GUU84_RS18450 3887830..3888225 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GUU84_RS18455 3888227..3888523 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GUU84_RS18460 3888728..3889210 - 483 WP_000183505.1 transcriptional regulator -
GUU84_RS18465 3889263..3889655 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GUU84_RS18470 3889807..3890466 + 660 WP_001221493.1 two-component system response regulator QseB -
GUU84_RS18475 3890463..3891812 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
GUU84_RS18480 3891858..3892190 - 333 WP_000917684.1 DUF2645 family protein -
GUU84_RS18485 3892509..3893090 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
GUU84_RS18490 3893121..3893435 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T147124 WP_000415584.1 NZ_CP047662:c3888523-3888227 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T147124 NZ_CP062867:c110531-110373 [Escherichia coli O39:H21]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT147124 WP_000650107.1 NZ_CP047662:c3888225-3887830 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT147124 NZ_CP062867:c110606-110575 [Escherichia coli O39:H21]
CACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References