Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 781223..781916 Replicon chromosome
Accession NZ_CP047658
Organism Escherichia coli strain LD39-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GUU82_RS03750 Protein ID WP_000415584.1
Coordinates 781223..781519 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GUU82_RS03755 Protein ID WP_000650107.1
Coordinates 781521..781916 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUU82_RS03715 776311..776625 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
GUU82_RS03720 776656..777237 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
GUU82_RS03725 777556..777888 + 333 WP_000917684.1 DUF2645 family protein -
GUU82_RS03730 777934..779283 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
GUU82_RS03735 779280..779939 - 660 WP_001221493.1 two-component system response regulator QseB -
GUU82_RS03740 780091..780483 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GUU82_RS03745 780536..781018 + 483 WP_000183505.1 transcriptional regulator -
GUU82_RS03750 781223..781519 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GUU82_RS03755 781521..781916 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GUU82_RS03760 782049..783656 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GUU82_RS03765 783794..786052 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T147075 WP_000415584.1 NZ_CP047658:781223-781519 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T147075 NZ_CP062862:17172-17453 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT147075 WP_000650107.1 NZ_CP047658:781521-781916 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT147075 NZ_CP062862:16906-17175 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References