Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4739599..4740173 Replicon chromosome
Accession NZ_CP047656
Organism Paraglaciecola mesophila strain GPM4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FX988_RS20340 Protein ID WP_160181887.1
Coordinates 4739599..4739877 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FX988_RS20345 Protein ID WP_160181888.1
Coordinates 4739877..4740173 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX988_RS20320 4735093..4735548 + 456 WP_201751611.1 potassium channel family protein -
FX988_RS20325 4735552..4736412 + 861 WP_201751612.1 hypothetical protein -
FX988_RS20330 4736482..4737549 - 1068 WP_160181886.1 integron integrase -
FX988_RS20335 4739029..4739447 + 419 Protein_3987 hypothetical protein -
FX988_RS20340 4739599..4739877 + 279 WP_160181887.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FX988_RS20345 4739877..4740173 + 297 WP_160181888.1 HigA family addiction module antidote protein Antitoxin
FX988_RS20350 4740317..4740550 + 234 WP_044056436.1 hypothetical protein -
FX988_RS20355 4740724..4741146 + 423 WP_160181889.1 plasmid pRiA4b ORF-3 family protein -
FX988_RS20360 4741347..4741601 + 255 WP_160181890.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
FX988_RS20365 4741594..4741857 + 264 WP_160181891.1 Txe/YoeB family addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10787.40 Da        Isoelectric Point: 9.6753

>T147071 WP_160181887.1 NZ_CP047656:4739599-4739877 [Paraglaciecola mesophila]
MIKSFIHKGLQKFYAKGTTSGIQKKHEKKLRLILSNLDQAETPDDMDLPGLYMHKLKGNRNDIWSVRVSGNWRVTYCFVG
RDVEIVNYEDYH

Download         Length: 279 bp

>T147071 NZ_CP062858:c41460-41278 [Escherichia coli O20:H12]
ATGATGGAGATATTCTGGACCATGCTGACCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11049.76 Da        Isoelectric Point: 6.9875

>AT147071 WP_160181888.1 NZ_CP047656:4739877-4740173 [Paraglaciecola mesophila]
MNMHNPAHPGEILKDLVIDALELTITDVAQHLDVSRKTLSKVLNGNGAITPEMALRLELVFGKPSAAHWLRLQNAFDLWQ
TRQYQSSLHVSPYNMTMV

Download         Length: 297 bp

>AT147071 NZ_CP062858:c41654-41457 [Escherichia coli O20:H12]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References