Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1828733..1828917 Replicon chromosome
Accession NZ_CP047646
Organism Staphylococcus aureus strain 19/Msa0875

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag GQ601_RS08540 Protein ID WP_000482647.1
Coordinates 1828733..1828840 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1828857..1828917 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQ601_RS08515 (GQ601_08565) 1824090..1824563 + 474 WP_000456489.1 GyrI-like domain-containing protein -
GQ601_RS08520 (GQ601_08570) 1824686..1825897 - 1212 WP_001191974.1 multidrug effflux MFS transporter -
GQ601_RS08525 (GQ601_08575) 1826085..1826744 - 660 WP_000831300.1 hypothetical protein -
GQ601_RS08530 (GQ601_08580) 1826804..1827946 - 1143 WP_001176859.1 glycerate kinase -
GQ601_RS08535 (GQ601_08585) 1828213..1828599 + 387 WP_000779355.1 flippase GtxA -
GQ601_RS08540 (GQ601_08590) 1828733..1828840 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1828857..1828917 - 61 - - Antitoxin
GQ601_RS08545 (GQ601_08595) 1829544..1831307 + 1764 WP_001064818.1 ABC transporter ATP-binding protein -
GQ601_RS08550 (GQ601_08600) 1831332..1833065 + 1734 WP_000486511.1 ABC transporter ATP-binding protein -
GQ601_RS08555 (GQ601_08605) 1833296..1833463 + 168 WP_001798790.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T147015 WP_000482647.1 NZ_CP047646:1828733-1828840 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T147015 NZ_CP062851:c1772559-1772182 [Escherichia coli O9:H10]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 61 bp

>AT147015 NZ_CP047646:c1828917-1828857 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7


Antitoxin

Download structure file

References