146975

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 351113..351759 Replicon chromosome
Accession NZ_CP047633
Organism Klebsiella pneumoniae strain K2606

Toxin (Protein)


Gene name higB Uniprot ID A6TF46
Locus tag GUY22_RS01645 Protein ID WP_015959099.1
Coordinates 351113..351460 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag GUY22_RS01650 Protein ID WP_004174017.1
Coordinates 351460..351759 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUY22_RS01635 347039..348472 + 1434 WP_002920564.1 glycogen synthase GlgA -
GUY22_RS01640 348490..350937 + 2448 WP_002920561.1 glycogen phosphorylase -
GUY22_RS01645 351113..351460 + 348 WP_015959099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUY22_RS01650 351460..351759 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
GUY22_RS01655 351822..353330 - 1509 WP_015959098.1 glycerol-3-phosphate dehydrogenase -
GUY22_RS01660 353535..353864 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
GUY22_RS01665 353915..354745 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
GUY22_RS01670 354795..355553 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13519.49 Da        Isoelectric Point: 6.2327

>T146975 WP_015959099.1 NZ_CP047633:351113-351460 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMNTLADREFSQHLTKER

Download         Length: 348 bp

>T146975 NZ_CP062837:c78746-78540 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGAGAGGTCAAAGTTTATGACGAAATATACCCTTATCGG
GGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAGCTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT146975 WP_004174017.1 NZ_CP047633:351460-351759 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT146975 NZ_CP062837:78733-78794 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TF46

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References