Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 12317..12846 Replicon plasmid pLraf_19_5_1
Accession NZ_CP047617
Organism Lactococcus raffinolactis strain Lr_19_5

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GU336_RS12685 Protein ID WP_167839261.1
Coordinates 12580..12846 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GU336_RS12680 Protein ID WP_167839260.1
Coordinates 12317..12580 (+) Length 88 a.a.

Genomic Context

GU336_RS12670GU336_RS12675GU336_RS12680GU336_RS12685GU336_RS12690GU336_RS12695GU336_RS12700
Location: 7725..10238 (2514 bp)
Type: Others
Protein ID: WP_167839258.1
Location: 10324..12240 (1917 bp)
Type: Others
Protein ID: WP_167839259.1
Location: 12317..12580 (264 bp)
Type: Antitoxin
Protein ID: WP_167839260.1
Location: 12580..12846 (267 bp)
Type: Toxin
Protein ID: WP_167839261.1
Location: 12869..13501 (633 bp)
Type: Others
Protein ID: WP_167839262.1
Location: 13577..16963 (3387 bp)
Type: Others
Protein ID: WP_167839263.1
Location: 17071..17367 (297 bp)
Type: Others
Protein ID: WP_167839264.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GU336_RS126707725..10238+2514WP_167839258.1type IV secretory system conjugative DNA transfer family protein-
GU336_RS1267510324..12240+1917WP_167839259.1hypothetical protein-
GU336_RS1268012317..12580+264WP_167839260.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GU336_RS1268512580..12846+267WP_167839261.1Txe/YoeB family addiction module toxinToxin
GU336_RS1269012869..13501+633WP_167839262.1hypothetical protein-
GU336_RS1269513577..16963+3387WP_167839263.1LPXTG cell wall anchor domain-containing protein-
GU336_RS1270017071..17367+297WP_167839264.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidmsr(D) / mef(A)-1..8261282612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10487.84 Da        Isoelectric Point: 9.7990

>T146971 WP_167839261.1 NZ_CP047617:12580-12846 [Lactococcus raffinolactis]
MANYQVVIKNSAKNDLKKLKQSNLKSSFLDIVETLANDPYEQSQSFEKLQPKKEGRYSRRINHQHRVVYKVNEELKQVEI
YSAWSHYE

Download         Length: 267 bp

>T146971 NZ_CP062833:56649-57029 [Escherichia coli]
ATGAGACATATATCACCGGAAGAACTTGTTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9855.86 Da        Isoelectric Point: 4.1953

>AT146971 WP_167839260.1 NZ_CP047617:12317-12580 [Lactococcus raffinolactis]
MTELSLSPSNARKNFYQLLKDVNANHSQVEIVSDRTGNNAVLISLSDWHSIQETLFLEQVGVMDKVRERENDDTGFSAVS
ELDWDSL

Download         Length: 264 bp

>AT146971 NZ_CP062833:56428-56649 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References