Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3471835..3472528 Replicon chromosome
Accession NZ_CP047609
Organism Escherichia coli strain NMBU_ W06E18

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag GU332_RS16805 Protein ID WP_000415584.1
Coordinates 3472232..3472528 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag GU332_RS16800 Protein ID WP_000650107.1
Coordinates 3471835..3472230 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GU332_RS16790 3467699..3469957 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
GU332_RS16795 3470095..3471702 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
GU332_RS16800 3471835..3472230 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
GU332_RS16805 3472232..3472528 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
GU332_RS16810 3472733..3473215 - 483 WP_000183505.1 transcriptional regulator -
GU332_RS16815 3473268..3473660 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
GU332_RS16820 3473812..3474471 + 660 WP_001221493.1 two-component system response regulator QseB -
GU332_RS16825 3474468..3475817 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
GU332_RS16830 3475863..3476195 - 333 WP_023149630.1 DUF2645 family protein -
GU332_RS16835 3476514..3477095 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
GU332_RS16840 3477126..3477440 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T146954 WP_000415584.1 NZ_CP047609:c3472528-3472232 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T146954 NZ_CP062832:661007-661321 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT146954 WP_000650107.1 NZ_CP047609:c3472230-3471835 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT146954 NZ_CP062832:661318-661734 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References