Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1547791..1548296 Replicon chromosome
Accession NZ_CP047606
Organism Citrobacter sp. LUTT5

Toxin (Protein)


Gene name yoeB Uniprot ID A0A5H6P158
Locus tag GUC46_RS07285 Protein ID WP_023218457.1
Coordinates 1547791..1548051 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5H6P2W8
Locus tag GUC46_RS07290 Protein ID WP_052932205.1
Coordinates 1548051..1548296 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC46_RS07265 1543345..1543938 - 594 WP_003845054.1 Slp family lipoprotein -
GUC46_RS07270 1544062..1544316 - 255 WP_044714077.1 DUF1471 domain-containing protein -
GUC46_RS07275 1544836..1546734 + 1899 WP_049002112.1 methyl-accepting chemotaxis protein -
GUC46_RS07280 1546909..1547538 + 630 WP_003028217.1 DNA-binding protein -
GUC46_RS07285 1547791..1548051 - 261 WP_023218457.1 Txe/YoeB family addiction module toxin Toxin
GUC46_RS07290 1548051..1548296 - 246 WP_052932205.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GUC46_RS07295 1548779..1549041 + 263 Protein_1420 ogr/Delta-like zinc finger family protein -
GUC46_RS07300 1549234..1549539 - 306 WP_087878867.1 hypothetical protein -
GUC46_RS07305 1550062..1550349 + 288 Protein_1422 hypothetical protein -
GUC46_RS07310 1551806..1553008 + 1203 WP_160179992.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - acrB 1526605..1554039 27434


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10202.88 Da        Isoelectric Point: 10.2570

>T146911 WP_023218457.1 NZ_CP047606:c1548051-1547791 [Citrobacter sp. LUTT5]
MKVRISPQAKSDLQYWAETDPKTHNKVMELIKSAKESPFKGIGKPEALKHRKPLWSRRITKEHRLVYYVEQGDLYIVACR
YHYTTI

Download         Length: 261 bp

>T146911 NZ_CP062824:c2575677-2575504 [Escherichia coli O167:H26]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9036.05 Da        Isoelectric Point: 4.4180

>AT146911 WP_052932205.1 NZ_CP047606:c1548296-1548051 [Citrobacter sp. LUTT5]
MQHVNYTDARQHLADLMQQANDDRAPILVTRKGAKSVVMIDAEEFASIQETLHLFSNPANAAHIEASLASLERGDYEELD
I

Download         Length: 246 bp

>AT146911 NZ_CP062824:c2576001-2575705 [Escherichia coli O167:H26]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGATTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H6P158

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6P2W8

References