146897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1926124..1926784 Replicon chromosome
Accession NZ_CP047604
Organism Klebsiella sp. MPUS7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GUC22_RS09035 Protein ID WP_049089248.1
Coordinates 1926124..1926477 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1DQ94
Locus tag GUC22_RS09040 Protein ID WP_004132739.1
Coordinates 1926482..1926784 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GUC22_RS09010 1921508..1922275 - 768 WP_004132727.1 molybdopterin-dependent oxidoreductase -
GUC22_RS09015 1922265..1922873 - 609 WP_004132729.1 cytochrome b/b6 domain-containing protein -
GUC22_RS09020 1922888..1923514 - 627 WP_004132731.1 hypothetical protein -
GUC22_RS09025 1923654..1924322 + 669 WP_004132733.1 heavy metal response regulator transcription factor -
GUC22_RS09030 1924322..1925740 + 1419 WP_160183491.1 heavy metal sensor histidine kinase -
GUC22_RS09035 1926124..1926477 + 354 WP_049089248.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GUC22_RS09040 1926482..1926784 + 303 WP_004132739.1 XRE family transcriptional regulator Antitoxin
GUC22_RS09045 1926978..1927181 + 204 Protein_1772 hypothetical protein -
GUC22_RS09050 1927182..1927515 + 334 Protein_1773 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13639.64 Da        Isoelectric Point: 9.8874

>T146897 WP_049089248.1 NZ_CP047604:1926124-1926477 [Klebsiella sp. MPUS7]
VWMIKTTDTFERWFTSLNDTDRARVLAALLVLREKGPGLSRPYADTLRGSRYSDMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE

Download         Length: 354 bp

>T146897 NZ_CP062821:c4170669-4170352 [Providencia rettgeri]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGAAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGAGCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11072.83 Da        Isoelectric Point: 5.7424

>AT146897 WP_004132739.1 NZ_CP047604:1926482-1926784 [Klebsiella sp. MPUS7]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL

Download         Length: 303 bp

>AT146897 NZ_CP062821:c4170937-4170650 [Providencia rettgeri]
ATGTCAACACTATTGAAAACAACAGATGTTCGTAGTCGAATTGATGAACAATTAAAAGCGGAAGCCACGAGTGTATTACA
AGATTGTGGTTTGACTATTAGCGCAGCTATTCGTTTGTTTTTAGAGCAAGTAGTTCAAGAGCAAAGAGTTCCCTTTGAAA
TCAAACGTAAGCAACCTTCGCTGAAAACTACACTAGCGTTGAAAGAAGCTAAAGCTATTGAGCAGCACTACGATTCAATT
AACGAAATGATGGTGGAGTTAAGCAAAGTTGACTCAGAAGCCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References