Detailed information of TA system TA146771

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2014018..2014276
• Replicon: chromosome
• Accession: NZ_CP047576
• Organism: Escherichia coli strain 94EC

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: GUJ28_RS09650
• Protein ID: WP_000809172.1
• Coordinates: 2014124..2014276 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2014018..2014075 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GUJ28_RS09630	2009044..2010396	+	1353	Protein_1888	fimbria/pilus outer membrane usher protein	-
GUJ28_RS09635	2010409..2011368	+	960	Protein_1889	fimbrial family protein	-
GUJ28_RS09640	2011407..2012306	-	900	WP_001300855.1	transcriptional activator NhaR	-
GUJ28_RS09645	2012372..2013538	-	1167	WP_000681359.1	Na+/H+ antiporter NhaA	-
-	2014018..2014075	-	58	-	-	Antitoxin
GUJ28_RS09650	2014124..2014276	+	153	WP_000809172.1	type I toxin-antitoxin system toxin MokC	Toxin
GUJ28_RS09655	2014380..2015510	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
GUJ28_RS09660	2015599..2017515	-	1917	WP_000516135.1	molecular chaperone DnaK	-
GUJ28_RS09665	2017892..2018296	+	405	WP_000843558.1	DUF2541 family protein	-
GUJ28_RS09670	2018322..2019035	+	714	WP_001102385.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5529.62 Da
• Isoelectric Point: 7.1312

>T146771 WP_000809172.1 NZ_CP047576:2014124-2014276 [Escherichia coli]
MKQHKAMIVALIVICITAVVAVLVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T146771 NZ_CP062780:4822632-4822973 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT146771 NZ_CP047576:c2014075-2014018 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin