146613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 196455..197057 Replicon chromosome
Accession NZ_CP047548
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10169

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag DXN26_RS00980 Protein ID WP_001159630.1
Coordinates 196455..196766 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DXN26_RS00985 Protein ID WP_000362050.1
Coordinates 196767..197057 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DXN26_RS00945 (191568) 191568..192167 + 600 WP_000965695.1 glucose-1-phosphatase -
DXN26_RS00950 (192161) 192161..193033 + 873 WP_000921427.1 virulence factor BrkB family protein -
DXN26_RS00955 (193030) 193030..193467 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
DXN26_RS00960 (193512) 193512..194453 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
DXN26_RS00965 (194468) 194468..194914 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
DXN26_RS00970 (194911) 194911..195222 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
DXN26_RS00975 (195308) 195308..196237 - 930 WP_001127703.1 alpha/beta hydrolase -
DXN26_RS00980 (196455) 196455..196766 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
DXN26_RS00985 (196767) 196767..197057 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
DXN26_RS00990 (197104) 197104..198033 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
DXN26_RS00995 (198030) 198030..198665 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
DXN26_RS01000 (198662) 198662..199564 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T146613 WP_001159630.1 NZ_CP047548:196455-196766 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T146613 NZ_CP062766:3154648-3154755 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT146613 WP_000362050.1 NZ_CP047548:196767-197057 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT146613 NZ_CP062766:c3154600-3154541 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References