Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 57393..57657 | Replicon | plasmid unnamedB |
| Accession | NZ_CP047539 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SJTUF10405 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | DXN32_RS26155 | Protein ID | WP_001387489.1 |
| Coordinates | 57505..57657 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 57393..57453 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DXN32_RS26135 (52896) | 52896..54104 | - | 1209 | WP_001703845.1 | IncI1-type conjugal transfer protein TrbA | - |
| DXN32_RS26140 (54421) | 54421..55620 | - | 1200 | WP_000948429.1 | IS91 family transposase | - |
| DXN32_RS26145 (55630) | 55630..55818 | - | 189 | WP_000957857.1 | hypothetical protein | - |
| DXN32_RS26150 (56099) | 56099..56878 | - | 780 | WP_275450201.1 | protein FinQ | - |
| - (57393) | 57393..57453 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (57393) | 57393..57453 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (57393) | 57393..57453 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (57393) | 57393..57453 | - | 61 | NuclAT_0 | - | Antitoxin |
| DXN32_RS26155 (57505) | 57505..57657 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| DXN32_RS26160 (57729) | 57729..57980 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| DXN32_RS26385 (58481) | 58481..58576 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| DXN32_RS26170 (58641) | 58641..58817 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| DXN32_RS26175 (59208) | 59208..59417 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| DXN32_RS26180 (59489) | 59489..60151 | - | 663 | WP_012783935.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| DXN32_RS26185 (60222) | 60222..62390 | - | 2169 | WP_015508354.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-14 | - | 1..88993 | 88993 | |
| - | flank | IS/Tn | - | - | 54421..55620 | 1199 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T146508 WP_001387489.1 NZ_CP047539:57505-57657 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T146508 NZ_CP062756:51523-51828 [Escherichia coli O157:H7]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 61 bp
>AT146508 NZ_CP047539:c57453-57393 [Salmonella enterica subsp. enterica serovar Typhimurium]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
